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hydroxyacid oxidase 1

Summary

Gene Symbol

HAO1

Aliases

GOX
glycolate oxidase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54363

HGNC

4809

KEGG Gene ID

hsa:54363

PubChem

54363

Alliance of Genome Resources

HGNC:4809

Annotation

Keyword

3D-structure
Amino-acid biosynthesis
FMN
Oxidoreductase
Peroxisome
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UJM8	Glycolate oxidase Glyoxylate oxidase
A8K058

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
response to oxidative stress	IEA
glycine biosynthetic process	IEA
fatty acid alpha-oxidation	IBA IDA	18215067
glycolate catabolic process	IDA	18215067

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

glycolate metabolic process [inference]

glycolate catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid alpha-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid alpha-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

glycolate metabolic process [inference]

glycolate catabolic process

primary alcohol catabolic process [inference]

glycolate catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

glycolate metabolic process [inference]

glycolate catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

glycolate metabolic process [inference]

glycolate catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid alpha-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

glycolate metabolic process [inference]

glycolate catabolic process

primary alcohol catabolic process [inference]

glycolate catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

glycolate catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

glycine metabolic process [inference]

glycine biosynthetic process

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

glycolate metabolic process [inference]

glycolate catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

glycolate catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

glycine biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid alpha-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
cytosol
peroxisomal matrix	IBA IDA TAS	10777549

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
FMN binding	IDA	18215067
(S)-2-hydroxy-acid oxidase activity	IBA IDA	10777549 18215067
glyoxylate oxidase activity	IDA	10777549 17669354

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [inference]

(S)-2-hydroxy-acid oxidase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [inference]

glyoxylate oxidase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

ribonucleotide binding [inference]

FMN binding

ion binding [inference]

anion binding [inference]

FMN binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

ribonucleotide binding [inference]

FMN binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

FMN binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000101323

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K11517

Name

(S)-2-hydroxy-acid oxidase [EC:1.1.3.15]

References

10777549

Rhea

O₂ + a (2S)-2-hydroxycarboxylate

H₂O₂ + a 2-oxocarboxylate

Enzyme

1.1.3.15

PMID

O₂ + glycolate

H₂O₂ + glyoxylate

Enzyme

1.1.3.15

PMID

H₂O + O₂ + glyoxylate

H⁺ + H₂O₂ + oxalate

Enzyme

1.2.3.5

PMID

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0070218	familial hyperinsulinemic hypoglycemia 2	DisGeNET
DOID:0070219	familial hyperinsulinemic hypoglycemia 1	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:13317	hyperinsulinemic hypoglycemia	DisGeNET
DOID:2977	primary hyperoxaluria	DisGeNET DisGeNET
DOID:580	uric acid nephrolithiasis	DisGeNET DisGeNET
DOID:585	nephrolithiasis	DisGeNET DisGeNET DisGeNET
DOID:655	inherited metabolic disorder	DisGeNET

Ortholog

Displaying entries **1 - 10** of 77 in total

1

2

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179241	WB:WBGene00018286
Drosophila melanogaster	3771779	FB:FBgn0061356
Callorhinchus milii	103186438		CALMI34665
Latimeria chalumnae	102364087		LATCH16942
Danio rerio	402827	ZFIN:ZDB-GENE-060519-2	DANRE12458
Astyanax mexicanus	103034843		ASTMX01410
Ictalurus punctatus	108270214		ICTPU35688
Electrophorus electricus	113572674		ELEEL13345
Salmo trutta	115162207		SALTR57795
Oreochromis niloticus	100701686		ORENI55924

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024