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formin 2

Summary

Gene Symbol

Fmn2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54418

PubChem

54418

Alliance of Genome Resources

MGI:1859252

Annotation

Keyword

Actin-binding
Cell membrane
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
DNA damage
Developmental protein
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JL04

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
actin cytoskeleton organization	IBA ISO
polar body extrusion after meiotic divisions	IMP	12447394
negative regulation of protein catabolic process	ISO ISS
protein transport	IEA
formin-nucleated actin cable assembly	IBA IMP ISO ISS	21620703

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

microtubule-based movement [inference]

chromosome movement towards spindle pole [inference]

meiotic chromosome movement towards spindle pole

homologous chromosome movement towards spindle pole in meiosis I anaphase

vesicle-mediated transport

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

meiotic cytokinesis [inference]

polar body extrusion after meiotic divisions

chromosome movement towards spindle pole [inference]

meiotic chromosome movement towards spindle pole

homologous chromosome movement towards spindle pole in meiosis I anaphase

spindle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

meiotic cell cycle process [inference]

meiotic chromosome movement towards spindle pole

homologous chromosome movement towards spindle pole in meiosis I anaphase

meiotic cytokinesis [inference]

polar body extrusion after meiotic divisions

establishment of meiotic spindle localization

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

polar body extrusion after meiotic divisions

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cell motility [inference]

cell migration

cellular localization [inference]

intracellular transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

actin cytoskeleton organization

cellular component assembly [inference]

actin filament bundle assembly

parallel actin filament bundle assembly [inference]

formin-nucleated actin cable assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin nucleation

actin filament bundle organization [inference]

actin filament bundle assembly

parallel actin filament bundle assembly [inference]

formin-nucleated actin cable assembly

formin-nucleated actin cable organization [inference]

formin-nucleated actin cable assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

polar body extrusion after meiotic divisions

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

meiotic cell cycle process [inference]

meiotic chromosome movement towards spindle pole

homologous chromosome movement towards spindle pole in meiosis I anaphase

meiotic cytokinesis [inference]

polar body extrusion after meiotic divisions

establishment of meiotic spindle localization

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport

establishment of spindle localization [inference]

establishment of meiotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

organelle localization [inference]

chromosome localization [inference]

chromosome movement towards spindle pole [inference]

meiotic chromosome movement towards spindle pole

homologous chromosome movement towards spindle pole in meiosis I anaphase

spindle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

cellular localization [inference]

intracellular transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA
actin filament	IEA
actin cytoskeleton	ISO ISS
endoplasmic reticulum	IDA	23439682 28992324
nucleus	IBA ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell cortex

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying **all 2** entries
GO Term	Evidence Code	PMID
actin binding	ISO ISS
microtubule binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

tubulin binding [inference]

microtubule binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

formin-2

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081211	autosomal recessive intellectual developmental disorder 47	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 63** of 63 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Psammomys obesus	129677851	48139_1:0002d0
Chionomys nivalis	130874099	269649_0:00193f
Peromyscus eremicus	131925032	42410_0:003fe9

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024