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N-acylsphingosine amidohydrolase 2

Summary

Gene Symbol

Asah2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54447

PubChem

54447

Alliance of Genome Resources

MGI:1859310

Annotation

Keyword

Apoptosis
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Golgi apparatus
Hydrolase
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Sphingolipid metabolism
Transmembrane helix
Ubl conjugation
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B9EHG7
Q9JHE3	Acylsphingosine deacylase 2 N-acylsphingosine amidohydrolase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA IDA ISO	14651853 18614015 21613224
Golgi membrane	IEA
extracellular space	IDA ISO	16126722
caveola	IDA	12921776
extracellular exosome	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12921776
zinc ion binding	ISO ISS
phytoceramidase activity
dihydroceramidase activity
ceramidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acylsphingosine amidohydrolase activity

ceramidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neutral ceramidase

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 9** entries
Gene Ontology
N-acylsphingosine amidohydrolase activity
ceramidase activity
ceramide catabolic process
ceramide metabolic process
hydrolase activity
lipid metabolic process
long-chain fatty acid biosynthetic process
sphingolipid metabolic process
sphingosine biosynthetic process

Displaying **all 4** entries
InterPro
Neutral ceramidase, C-terminal domain superfamily
Neutral/alkaline non-lysosomal ceramidase, C-terminal
Neutral/alkaline non-lysosomal ceramidase, N-terminal
Neutral/alkaline nonlysosomal ceramidase

Rhea

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006314
Gene Name: N-acylsphingosine amidohydrolase 2

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43618		FB:FBgn0039774
Homo sapiens	56624		HGNC:18860	HUMAN01150
Rattus norvegicus	114104	10116_1:000b4e	RGD:69410	RATNO18782
Pan troglodytes	450461			PANTR00634
Danio rerio	493602		ZFIN:ZDB-GENE-041112-1	DANRE04386
Homo sapiens	653308		HGNC:23456
Macaca mulatta	703913			MACMU46121
Equus caballus	100071829			HORSE16348
Ornithorhynchus anatinus	100075060			ORNAN17698
Sus scrofa	100157065			PIGXX08073

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements