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N-acylsphingosine amidohydrolase 2

Summary

Gene Symbol

Asah2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54447

PubChem

54447

Alliance of Genome Resources

MGI:1859310

Annotation

Keyword

Apoptosis
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Golgi apparatus
Hydrolase
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Sphingolipid metabolism
Transmembrane helix
Ubl conjugation
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B9EHG7
Q9JHE3	Acylsphingosine deacylase 2 N-acylsphingosine amidohydrolase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
membrane	IDA	10753931
Golgi apparatus	ISO ISS
plasma membrane	IDA ISO	12921776 16126722
membrane raft	ISO
extracellular region	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12921776
zinc ion binding	ISO ISS
phytoceramidase activity
dihydroceramidase activity
ceramidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acylsphingosine amidohydrolase activity

ceramidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neutral ceramidase

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 9** entries
Gene Ontology
N-acylsphingosine amidohydrolase activity
ceramidase activity
ceramide catabolic process
ceramide metabolic process
hydrolase activity
lipid metabolic process
long-chain fatty acid biosynthetic process
sphingolipid metabolic process
sphingosine biosynthetic process

Displaying **all 4** entries
InterPro
Neutral ceramidase, C-terminal domain superfamily
Neutral/alkaline non-lysosomal ceramidase, C-terminal
Neutral/alkaline non-lysosomal ceramidase, N-terminal
Neutral/alkaline nonlysosomal ceramidase

Rhea

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006314
Gene Name: N-acylsphingosine amidohydrolase 2

Ortholog

Displaying entries **31 - 40** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ictidomys tridecemlineatus	101962060	43179_0:003c30
Microtus ochrogaster	102000249	79684_0:0015b4
Chinchilla lanigera	102003466	34839_0:0018f2		CHILA07895
Capra hircus	102183481			CAPHI18028
Latimeria chalumnae	102355598			LATCH06760
Peromyscus maniculatus bairdii	102917313	230844_0:00027d
Astyanax mexicanus	103021762			ASTMX15617
Callorhinchus milii	103180876			CALMI02982
Chlorocebus sabaeus	103216197			CHLSB17914
Carlito syrichta	103273221			CARSF09069

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024