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cytochrome p450 oxidoreductase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

5447

PubChem

5447

Alliance of Genome Resources

HGNC:9208

Annotation

Keyword

3D-structure
Acetylation
Congenital adrenal hyperplasia
Craniosynostosis
Direct protein sequencing
Disease variant
Endoplasmic reticulum
FAD
FMN
NADP
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A9L9PY49
P16435

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
xenobiotic metabolic process	TAS
nitric oxide biosynthetic process	IBA
response to hormone	IBA
electron transport chain	IDA	10048323 2513880
positive regulation of monooxygenase activity	IDA	19448135

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process [inference]

nitric oxide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain

xenobiotic metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular organohalogen metabolic process [inference]

cellular organofluorine metabolic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain

xenobiotic metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular organohalogen metabolic process [inference]

cellular organofluorine metabolic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone

biological regulation [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
cytosol	IBA
membrane	HDA	19946888
intracellular membrane-bounded organelle	IDA	9618440

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
NADPH-hemoprotein reductase activity	TAS
NADPH-hemoprotein reductase activity	IDA	10048323 19448135 2513880
NADPH-hemoprotein reductase activity	IBA
protein binding	IPI	21081644 35271311
FMN binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [inference]

NADPH-hemoprotein reductase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ribonucleotide binding [inference]

FMN binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ribonucleotide binding [inference]

FMN binding

flavin adenine dinucleotide binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

FMN binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
FMN binding
flavin adenine dinucleotide binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Flavoprotein pyridine nucleotide cytochrome reductase
NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Oxidoreductase FAD/NAD(P)-binding
Riboflavin synthase-like beta-barrel
Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050462	Antley-Bixler syndrome with disordered steroidogenesis	Alliance of Genome Resources
DOID:0050811	congenital adrenal hyperplasia	Alliance of Genome Resources
DOID:0080925	cytochrome P450 oxidoreductase deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5447	Xenbase:XB-GENE-951363
Mus musculus	18984	Xenbase:XB-GENE-951363	MOUSE46621
Rattus norvegicus	29441		RATNO05461
Danio rerio	327556		DANRE08988
Pan troglodytes	463481		PANTR40557
Canis lupus familiaris	489816		CANLF16157
Bos taurus	532512		BOVIN20772
Macaca mulatta	715888		MACMU31911
Equus caballus	100059789		HORSE06802
Cavia porcellus	100135602		CAVPO13456

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements