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ATR serine/threonine kinase
Summary
- Gene Symbol
-
- ATR
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Chromosome
- DNA repair
- DNA-binding
- Disease variant
- Dwarfism
- Intellectual disability
- Manganese
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Serine/threonine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13535 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA damage checkpoint signaling | ||
| DNA damage checkpoint signaling | ||
| telomere maintenance | ||
| nucleobase-containing compound metabolic process | ||
| DNA replication |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromosome, telomeric region | ||
| nucleus | ||
| nucleus | ||
| nuclear envelope | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA binding | ||
| protein kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity |
GO Hierarchy
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- protein serine kinase activity
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- protein serine kinase activity
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- protein serine kinase activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity
protein serine/threonine kinase activity
histone kinase activity [inference]
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity
protein serine/threonine kinase activity
histone kinase activity [inference]
catalytic activity, acting on a protein [inference]
protein kinase activity
protein serine/threonine kinase activity
histone kinase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070007 | Seckel syndrome 1 | |
| DOID:0080202 | adenoid cystic carcinoma | |
| DOID:1324 | lung cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 545 | Xenbase:XB-GENE-1012722 | ||
| 245000 | MOUSE62386 | ||
| 460745 | PANTR32360 | ||
| 567770 | DANRE29334 | ||
| 685055 | RATNO41864 | ||
| 714443 | MACMU29687 | ||
| 100073649 | ORNAN11920 | ||
| 100226379 | TAEGU30451 | ||
| 100359062 | RABIT04436 | ||
| 100412321 | CALJA14618 |
