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Guidelines

MIRAGE

pseudouridine synthase 7

Summary

Gene Symbol

PUS7

Organism

Homo sapiens (human)

External Links

NCBI Gene

54517

PubChem

54517

Alliance of Genome Resources

HGNC:26033

JoGo

PUS7

TogoVar

PUS7

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Dwarfism
Intellectual disability
Isomerase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
mRNA splicing
tRNA processing

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KY42
Q96PZ0
B3KRB2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
pseudouridine synthesis	IBA
mRNA processing	IEA
RNA splicing	IEA
negative regulation of translation	IDA	29628141
negative regulation of translation	IMP	35144859

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of mesoderm development

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IDA	29628141 35144859
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
pseudouridine synthase activity	IDA	29628141 31477916 35051350
pseudouridine synthase activity	IMP	28073919
pseudouridine synthase activity	IBA
enzyme binding	IPI	23382074

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

intramolecular transferase activity [inference]

pseudouridine synthase activity

binding [inference]

protein binding [inference]

enzyme binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pseudouridine synthase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 2** entries
Gene Ontology
isomerase activity
pseudouridine synthesis

Displaying **all 4** entries
InterPro
Pseudouridine synthase, TruD, catalytic domain
Pseudouridine synthase, TruD, insertion domain
Pseudouridine synthase, TruD
Pseudouridine synthase, catalytic domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081265	intellectual developmental disorder with abnormal behavior, microcephaly, and short stature	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026