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UDP glucuronosyltransferase family 1 member A8

Summary

Gene Symbol

UGT1A8

Aliases

UGT1H

Organism

Homo sapiens (human)

External Links

NCBI Gene

54576

HGNC

12540

KEGG Gene ID

hsa:54576

PubChem

54576

Alliance of Genome Resources

HGNC:12540

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Lipid metabolism
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9HAW9	UDP-glucuronosyltransferase 1-8 UDP-glucuronosyltransferase 1-H
Q5DSZ6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
flavonoid glucuronidation	IDA	20056724
steroid metabolic process	IC IDA	15472229 16595710 19996319 23288867
negative regulation of cellular glucuronidation	IDA	20610558
coumarin metabolic process	IC	19996319
xenobiotic metabolic process	IDA	20610558

GO Hierarchy

biological process

metabolic process [inference]

secondary metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process

pigment metabolic process [inference]

flavone metabolic process

hormone metabolic process [inference]

retinoic acid metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

cellular aromatic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process

xenobiotic metabolic process

xenobiotic glucuronidation

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

heterocycle metabolic process [inference]

coumarin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

flavonoid metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process

phenylpropanoid metabolic process [inference]

coumarin metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

cellular aromatic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process

xenobiotic metabolic process

xenobiotic glucuronidation

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

heterocycle metabolic process [inference]

coumarin metabolic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular metabolic process [inference]

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinoic acid metabolic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of glucuronosyltransferase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of glucuronosyltransferase activity

regulation of transferase activity [inference]

negative regulation of transferase activity [inference]

negative regulation of glucuronosyltransferase activity

regulation of glucuronosyltransferase activity [inference]

negative regulation of glucuronosyltransferase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA IKR IMR NAS	20610558
endoplasmic reticulum	IBA IDA NAS	17179145 20610558

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
enzyme binding	IBA IPI	17179145 20610558
fatty acid binding	IDA	19996319
steroid binding	IDA	19996319
protein heterodimerization activity	IEA IPI	20610558
retinoic acid binding	IC	20308471

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

organic cyclic compound binding [inference]

steroid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glucuronosyltransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
UDP-glycosyltransferase activity
transferase activity

Displaying 1 entry
InterPro
UDP-glucuronosyl/UDP-glucosyltransferase

KEGG BRITE Database

Orthology

K00699

Name

glucuronosyltransferase [EC:2.4.1.17]

References

Rhea

RHEA:21032

glucuronate acceptor + UDP-α-D-glucuronate

acceptor β-D-glucuronoside + H⁺ + UDP

Enzyme

2.4.1.17

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	24861		RATNO42391
Drosophila melanogaster	35105	FB:FBgn0032684
Drosophila melanogaster	35137	FB:FBgn0027074
Drosophila melanogaster	35138	FB:FBgn0032713
Drosophila melanogaster	35139	FB:FBgn0027070
Drosophila melanogaster	40079	FB:FBgn0036842
Drosophila melanogaster	41333	FB:FBgn0026314
Drosophila melanogaster	41334	FB:FBgn0026315
Drosophila melanogaster	41574	FB:FBgn0038083
Drosophila melanogaster	42538	FB:FBgn0038886

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements