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cardiolipin synthase 1

Summary

Gene Symbol

CRLS1

Aliases

CLS1
GCD10
GCD10 homolog (S. cerevisiae)
dJ967N21.6

Organism

Homo sapiens (human)

External Links

NCBI Gene

54675

HGNC

16148

KEGG Gene ID

hsa:54675

PubChem

54675

Alliance of Genome Resources

HGNC:16148

Annotation

Keyword

Alternative splicing
Disease variant
Mitochondrion inner membrane
Phospholipid biosynthesis
Primary mitochondrial disease
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UJA2	Protein GCD10 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cardiolipin biosynthetic process	TAS	38322995
cardiolipin biosynthetic process	IDA	16678169 16716149
cardiolipin biosynthetic process	IBA
phosphatidylglycerol acyl-chain remodeling	TAS
response to thyroxine	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

phosphatidylglycerol acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process [inference]

cardiolipin biosynthetic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone [inference]

response to thyroxine

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to thyroxine

response to organic substance [inference]

response to hormone [inference]

response to thyroid hormone [inference]

response to thyroxine

response to organonitrogen compound [inference]

response to amino acid [inference]

response to thyroxine

response to L-phenylalanine derivative [inference]

response to thyroxine

response to organic cyclic compound [inference]

response to thyroxine

response to lipid [inference]

response to phosphatidylethanolamine

response to organophosphorus [inference]

response to phosphatidylethanolamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to thyroxine

response to L-phenylalanine derivative [inference]

response to thyroxine

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to thyroxine

response to phosphatidylethanolamine

response to salt [inference]

response to thyroxine

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA	16716149 38322995
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial inner membrane	ISS
mitochondrial inner membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity	TAS
cardiolipin synthase (CMP-forming)	TAS
cardiolipin synthase (CMP-forming)	IDA	16678169 16716149
cardiolipin synthase (CMP-forming)	IMP	35147173
cardiolipin synthase (CMP-forming)	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

2-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity [inference]

lysophosphatidic acid acyltransferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

phosphatidyltransferase activity [inference]

cardiolipin synthase (CMP-forming)

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

synthase

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 7** entries
Gene Ontology
cardiolipin biosynthetic process
cardiolipin synthase (CMP-forming)
lipid metabolic process
phosphatidyltransferase activity
phospholipid biosynthetic process
phosphotransferase activity, for other substituted phosphate groups
transferase activity

Displaying **all 3** entries
InterPro
CDP-alcohol phosphatidyltransferase, conserved site
CDP-alcohol phosphatidyltransferase, transmembrane domain
CDP-alcohol phosphatidyltransferase

KEGG BRITE Database

Orthology

K08744

Name

cardiolipin synthase (CMP-forming) [EC:2.7.8.41]

References

Rhea

RHEA:32931

a CDP-1,2-diacyl-sn-glycerol + 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)

H⁺ + CMP + a cardiolipin

Enzyme

2.7.8.41

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070430	combined oxidative phosphorylation deficiency 57	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 34 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000407	Sensorineural hearing impairment
HP:0000639	Nystagmus
HP:0000710	Hyperorality
HP:0000863	Central diabetes insipidus
HP:0000873	Diabetes insipidus
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001332	Dystonia

Displaying 1 entry
Disease ID	Disease Name
OMIM:620167	combined oxidative phosphorylation deficiency 57

PubChem Disease

MedGen Diseases

Combined oxidative phosphorylation deficiency 57

OMIM Phenotypes

COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 57; COXPD57

KEGG Diseases

Combined oxidative phosphorylation deficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002801
Gene Name: cardiolipin synthase 1

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	54675	Xenbase:XB-GENE-979013
Mus musculus	66586		MOUSE35161
Rattus norvegicus	366196		RATNO26269
Pan troglodytes	458087		PANTR24332
Bos taurus	512761		BOVIN04704
Canis lupus familiaris	607530		CANLF09310
Equus caballus	100065537		HORSE21226
Ornithorhynchus anatinus	100083897		ORNAN26906
Callithrix jacchus	100406450		CALJA32699
Pongo abelii	100459367		PONAB20707

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements