GlyCosmos Portal

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GO Term	Evidence Code	PMID
procollagen-proline 4-dioxygenase activity	IBA
iron ion binding	IEA
calcium ion binding	IEA
2-oxoglutarate-dependent dioxygenase activity	IDA	22955912
L-ascorbic acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prolyl 4-hydroxylase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
L-ascorbic acid binding
calcium ion binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 7** entries
InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	54681	Xenbase:XB-GENE-950282
Mus musculus	74443	Xenbase:XB-GENE-950282	MOUSE62642
Rattus norvegicus	301008		RATNO41076
Bos taurus	538626		BOVIN17864
Macaca mulatta	708158		MACMU29433
Pan troglodytes	743155		PANTR31094
Danio rerio	799930		DANRE37964
Monodelphis domestica	100027342		MONDO29357
Equus caballus	100063429		HORSE12138
Ornithorhynchus anatinus	100074003		ORNAN29377