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pyruvate dehydrogenase phosphatase catalytic subunit 1

Summary

Gene Symbol

PDP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54704

PubChem

54704

Alliance of Genome Resources

HGNC:9279

Annotation

Keyword

Acetylation
Alternative splicing
Calcium
Disease variant
Magnesium
Manganese
Metal-binding
Mitochondrion
Protein phosphatase
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9P0J1	Protein phosphatase 2C Pyruvate dehydrogenase phosphatase catalytic subunit 1
Q6P1N1	Protein phosphatase 2C Pyruvate dehydrogenase phosphatase catalytic subunit 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
signal transduction	IBA
peptidyl-threonine dephosphorylation	IDA	20801214

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

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GO Term	Evidence Code	PMID
mitochondrion	NAS	6293549
mitochondrion	IDA	19184109
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

phosphatase complex [inference]

protein serine/threonine phosphatase complex [inference]

pyruvate dehydrogenase (lipoamide) phosphatase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein serine/threonine phosphatase activity	IDA	20801214
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IDA	15554715
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA
protein binding	IPI	25416956 32296183
[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

phosphatase regulator activity [inference]

protein phosphatase regulator activity [inference]

[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
PPM-type phosphatase-like domain superfamily
PPM-type phosphatase-like domain
Protein phosphatase 2C

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3649	pyruvate decarboxylase deficiency	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	54704	Xenbase:XB-GENE-481257
Rattus norvegicus	54705		RATNO34872
Bos taurus	280891		BOVIN06188
Mus musculus	381511		MOUSE42645
Pan troglodytes	472819		PANTR42951
Canis lupus familiaris	477941		CANLF11797
Danio rerio	558728		DANRE11003
Macaca mulatta	699172		MACMU43420
Monodelphis domestica	100029761		MONDO17269
Equus caballus	100051376		HORSE42357

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Acknowledgements