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vacuolar protein sorting 13 homolog C

Summary

Gene Symbol

VPS13C

Organism

Homo sapiens (human)

External Links

NCBI Gene

54832

PubChem

54832

Alliance of Genome Resources

HGNC:23594

JoGo

VPS13C

TogoVar

VPS13C

Annotation

Keyword

Acetylation
Alternative splicing
Disease variant
Endoplasmic reticulum
Endosome
Lipid droplet
Lipid transport
Lysosome
Methylation
Mitochondrion outer membrane
Neurodegeneration
Parkinson disease
Parkinsonism
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q709C8	Vacuolar protein sorting-associated protein 13C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
response to insulin	IEA
protein retention in Golgi apparatus	IBA
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	IMP	26942284

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

Golgi to endosome transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

intracellular transport [inference]

cytosolic transport [inference]

Golgi to endosome transport

organic substance transport [inference]

lipid transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of localization in cell [inference]

intracellular transport [inference]

cytosolic transport [inference]

Golgi to endosome transport

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

Golgi to endosome transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of response to stimulus [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of cellular process [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of mitochondrion organization [inference]

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular response to stress [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	TAS	20081857
mitochondrial outer membrane	IDA	26942284
lysosome	IDA	30093493
lysosomal membrane	IEA
late endosome	IDA	30093493

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

secretory granule membrane [inference]

dense core granule membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

secretory granule membrane [inference]

dense core granule membrane

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular non-membrane-bounded organelle [inference]

lipid droplet

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060896	Parkinson's disease 23	Alliance of Genome Resources

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Last updated: April 6, 2026

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