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Guidelines
MIRAGE
NOP2/Sun RNA methyltransferase 2

Summary
Gene Symbol
  • NSUN2
Organism
Homo sapiens (human)
NCBI Gene
54888
PubChem
54888
Alliance of Genome Resources
Annotation
Keyword
  • Acetylation
  • Alternative splicing
  • Cytoskeleton
  • Direct protein sequencing
  • Disease variant
  • Intellectual disability
  • Isopeptide bond
  • Methyltransferase
  • Mitochondrion
  • Mitosis
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • S-adenosyl-L-methionine
  • Secreted
  • Spermatogenesis
  • Ubl conjugation
  • tRNA processing
  • tRNA-binding
Proteins
Displaying 1 entry
UniProt Protein Name
Q08J23
  • Myc-induced SUN domain-containing protein
  • NOL1/NOP2/Sun domain family member 2
  • Substrate of AIM1/Aurora kinase B
  • mRNA cytosine C(5)-methyltransferase
  • tRNA cytosine C(5)-methyltransferase
  • tRNA methyltransferase 4 homolog
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 12 in total
GO Term Evidence Code PMID
in utero embryonic development
mRNA processing
tRNA modification
spermatid development
regulation of mRNA export from nucleus
GO Hierarchy
Displaying entries 1 - 5 of 7 in total
GO Term Evidence Code PMID
tRNA binding
RNA binding
protein binding
tRNA (cytidine-5-)-methyltransferase activity
tRNA (cytidine-5-)-methyltransferase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
methyltransferase
Functional Category
  • J: Translation, ribosomal structure and biogenesis
  • K: Transcription
  • L: Replication, recombination and repair
Displaying all 8 entries
Gene Ontology
RNA methylation
RNA methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
methylation
tRNA (cytidine-5-)-methyltransferase activity
tRNA methylation
tRNA processing
transferase activity
Displaying all 6 entries
InterPro
Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site
RNA (C5-cytosine) methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily
SAM-dependent methyltransferase RsmB-F/NOP2-type domain
SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
tRNA (C5-cytosine) methyltransferase, NCL1
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:0081181 autosomal recessive intellectual developmental disorder 5
Ortholog
Displaying entries 31 - 40 of 69 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
101953716 CHRPI19817
101968073 ICTTR00684
102023822 CHILA20772
102125748 MACFA35161
102180428 CAPHI13308
102428418 MYOLU00351
102452913 PELSI08673
103038375 ASTMX15807
103183195 CALMI26781
103214972 CHLSB13904
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025