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ADP-ribosylserine hydrolase

Summary

Gene Symbol

ADPRS

Aliases

ADP-ribosylarginine hydrolase like 2
ARH3
FLJ20446

Organism

Homo sapiens (human)

External Links

NCBI Gene

54936

HGNC

21304

PubChem

54936

Alliance of Genome Resources

HGNC:21304

Annotation

Keyword

3D-structure
Chromosome
Cytoplasm
DNA repair
Disease variant
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Neurodegeneration
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7ZAN4	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase
Q9NX46	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
peptidyl-serine ADP-deribosylation	IDA	28650317 29234005 33186521
cellular response to superoxide	IMP	30401461
base-excision repair, gap-filling	TAS
negative regulation of necroptotic process	ISS
DNA repair	IMP	30045870

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide [inference]

cellular response to superoxide

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

response to chemical [inference]

response to inorganic substance [inference]

response to oxygen radical [inference]

response to superoxide [inference]

cellular response to superoxide

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide [inference]

cellular response to superoxide

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IBA IDA	30045870 34479984
nuclear body	IDA
cytoplasm	IDA	34479984
site of DNA damage	IDA	30045870
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

site of DNA damage

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ADP-ribosylserine hydrolase activity	IDA	28650317 29234005 33186521 34625544 37268618
magnesium ion binding	IDA	30045870 33894202
poly(ADP-ribose) glycohydrolase activity	IDA IMP TAS	17075046 30830864 33769608 33894202 34019811 34321462 34479984
O-acetyl-ADP-ribose deacetylase activity	IDA	17075046 21498885
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

poly(ADP-ribose) glycohydrolase activity

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylserine hydrolase activity

deacetylase activity [inference]

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylserine hydrolase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000116863

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:52216

H₂O

ADP-D-ribose

Enzyme

3.2.1.143

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 24 in total

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DO ID	Disease Name	Source
DOID:9837	hypertropia	DisGeNET
DOID:9650	pathologic nystagmus	DisGeNET
DOID:0060260	ptosis	DisGeNET
DOID:0060261	congenital ptosis	DisGeNET
DOID:0070352	stress-induced childhood-onset neurodegeneration with variable ataxia and seizures	Alliance of Genome Resources
DOID:0090105	autosomal recessive hypercholesterolemia	DisGeNET
DOID:10127	cerebral artery occlusion	DisGeNET
DOID:1059	intellectual disability	DisGeNET
DOID:11771	spontaneous ocular nystagmus	DisGeNET
DOID:11832	visual epilepsy	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 28 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000508	Ptosis
HP:0000602	Ophthalmoplegia
HP:0000639	Nystagmus
HP:0000651	Diplopia
HP:0001250	Seizure
HP:0001251	Ataxia

Displaying 1 entry
Disease ID	Disease Name
OMIM:618170	neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures

PubChem Disease

MedGen Diseases

Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures

OMIM Phenotypes

NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES; CONDSIAS

KEGG Diseases

Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103185621		CALMI32708
Latimeria chalumnae	102353686		LATCH18702
Danio rerio	796446	ZFIN:ZDB-GENE-040912-85	DANRE12490
Astyanax mexicanus	103033656		ASTMX09676
Ictalurus punctatus	100528849		ICTPU35257
Electrophorus electricus	113576641		ELEEL19816
Salmo trutta	115162109		SALTR56414
Gadus morhua	115543550		GADMO49891
Oryzias latipes	101170235		ORYLA10674
Oreochromis niloticus	100707617		ORENI30931

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PubChem Disease

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Acknowledgements