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ADP-ribosylserine hydrolase

Summary

Gene Symbol

ADPRS

Aliases

ADP-ribosylarginine hydrolase like 2
ARH3
FLJ20446

Organism

Homo sapiens (human)

External Links

NCBI Gene

54936

HGNC

21304

PubChem

54936

Alliance of Genome Resources

HGNC:21304

Annotation

Keyword

3D-structure
Chromosome
Cytoplasm
DNA repair
Disease variant
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Neurodegeneration
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7ZAN4	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase
Q9NX46	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA repair	IMP	30045870
base-excision repair, gap-filling	TAS
negative regulation of necroptotic process	ISS
cellular response to superoxide	IMP	30401461
peptidyl-serine ADP-deribosylation	IDA	28650317 29234005 33186521

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide [inference]

cellular response to superoxide

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

response to chemical [inference]

response to inorganic substance [inference]

response to oxygen radical [inference]

response to superoxide [inference]

cellular response to superoxide

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide [inference]

cellular response to superoxide

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to oxygen radical [inference]

cellular response to superoxide

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	30045870 34479984
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IDA	34479984
mitochondrion	IDA	34479984

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

site of DNA damage

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA	30045870 33894202
hydrolase activity, hydrolyzing O-glycosyl compounds	IDA	30045870
poly(ADP-ribose) glycohydrolase activity	TAS
poly(ADP-ribose) glycohydrolase activity	IDA	17075046 30830864 33894202 34019811 34479984
poly(ADP-ribose) glycohydrolase activity	IMP	33769608 34321462

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

poly(ADP-ribose) glycohydrolase activity

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylserine hydrolase activity

deacetylase activity [inference]

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylserine hydrolase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ADP-ribose glycohydrolase ARH3

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 2** entries
InterPro
ADP-ribosylation/Crystallin J1 superfamily
ADP-ribosylation/Crystallin J1

Human Protein Atlas

ENSG00000116863

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:52216

H₂O

ADP-D-ribose

Enzyme

3.2.1.143

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070352	stress-induced childhood-onset neurodegeneration with variable ataxia and seizures	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 28 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000508	Ptosis
HP:0000602	Ophthalmoplegia
HP:0000639	Nystagmus
HP:0000651	Diplopia
HP:0001250	Seizure
HP:0001251	Ataxia

Displaying 1 entry
Disease ID	Disease Name
OMIM:618170	neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures

PubChem Disease

MedGen Diseases

Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures

OMIM Phenotypes

NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES; CONDSIAS

KEGG Diseases

Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	54936	Xenbase:XB-GENE-944445
Mus musculus	100206	Xenbase:XB-GENE-944445	MOUSE42138
Rattus norvegicus	362600		RATNO34402
Pan troglodytes	456750		PANTR20638
Bos taurus	521650		BOVIN27308
Xenopus tropicalis	548938	Xenbase:XB-GENE-944445
Macaca mulatta	712758		MACMU21042
Danio rerio	796446	Xenbase:XB-GENE-944445	DANRE12490
Monodelphis domestica	100031418		MONDO25414
Equus caballus	100069360		HORSE28488

GlyTouCan

GlyComb

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements