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protein phosphatase 1 catalytic subunit beta

Summary

Gene Symbol

PPP1CB

Organism

Homo sapiens (human)

External Links

NCBI Gene

5500

PubChem

5500

Alliance of Genome Resources

HGNC:9282

Annotation

Keyword

Acetylation
Biological rhythms
Cell division
Cytoplasm
Direct protein sequencing
Disease variant
Glycogen metabolism
Manganese
Metal-binding
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HW04
P62140

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
regulation of cell adhesion	IDA	20354225
MAPK cascade	TAS
entrainment of circadian clock by photoperiod	ISS
regulation of circadian rhythm	IBA IMP	21712997
circadian regulation of gene expression	IBA ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cell division

rhythmic process [inference]

circadian rhythm [inference]

circadian regulation of gene expression

response to stimulus [inference]

response to external stimulus [inference]

entrainment of circadian clock [inference]

entrainment of circadian clock by photoperiod

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

photoperiodism [inference]

entrainment of circadian clock by photoperiod

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of circadian rhythm

entrainment of circadian clock [inference]

entrainment of circadian clock by photoperiod

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

regulation of cell adhesion

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
focal adhesion	HDA	21423176
chromosome, telomeric region	IDA	24270157
nucleoplasm	IDA TAS
PTW/PP1 phosphatase complex	IDA	20354225 20516061
nucleus	HDA IBA	21630459

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

phosphatase complex [inference]

protein serine/threonine phosphatase complex [inference]

protein phosphatase type 1 complex [inference]

PTW/PP1 phosphatase complex

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
myosin phosphatase activity	ISS
protein serine/threonine phosphatase activity	IBA TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

myosin phosphatase activity

myosin-light-chain-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

myosin phosphatase activity

myosin-light-chain-phosphatase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
phosphoprotein phosphatase activity

Displaying **all 4** entries
InterPro
Calcineurin-like phosphoesterase domain, ApaH type
Metallo-dependent phosphatase-like
Serine/Threonine protein phosphatase PP2A-like
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080693	Noonan syndrome-like disorder with loose anagen hair 2	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 80** of 80 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Podarcis muralis	114594579		PODMU16874
Gadus morhua	115529750		GADMO20335
Sparus aurata	115589215		SPAAU08344
Strigops habroptila	115613414		STRHB13807
Corvus moneduloides	116441158		CORMO17369
Scophthalmus maximus	118301616		SCOMX25197
Balaenoptera musculus	118905689		BALMU05367
Panthera leo	122216474		PANLE02111
Ursus americanus	123799882		URSAM23214
Pongo pygmaeus	129030061	9600_0:0008db

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements