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VPS37C subunit of ESCRT-I

Summary

Gene Symbol

VPS37C

Organism

Homo sapiens (human)

External Links

NCBI Gene

55048

PubChem

55048

Alliance of Genome Resources

HGNC:26097

Annotation

Keyword

Endosome
Membrane
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A5D8V6	ESCRT-I complex subunit VPS37C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein targeting to membrane	IBA
protein targeting to vacuole	IBA
macroautophagy	TAS	20588296
multivesicular body assembly	NAS	32424346
multivesicular body assembly	TAS	20588296

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

endosome organization [inference]

multivesicular body organization [inference]

multivesicular body assembly

organelle assembly [inference]

multivesicular body assembly

cellular component assembly [inference]

organelle assembly [inference]

multivesicular body assembly

membrane organization [inference]

membrane fission

viral process [inference]

viral budding [inference]

viral budding via host ESCRT complex

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
ESCRT I complex	ISS
ESCRT I complex	TAS	20588296
ESCRT I complex	IDA	18005716 22405001
ESCRT I complex	IBA
ESCRT I complex	IPI	18005716 21757351

GO Hierarchy

cellular component

protein-containing complex [inference]

ESCRT complex [inference]

ESCRT I complex

membrane protein complex [inference]

ESCRT I complex

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

endosome membrane

late endosome membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17853893 23924735 25416956 31515488 32296183 35271311
calcium-dependent protein binding	IPI	23924735

GO Hierarchy

molecular function

binding [inference]

protein binding

calcium-dependent protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vacuolar protein sorting-associated

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
protein targeting to membrane
protein targeting to vacuole
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Displaying **all 3** entries
InterPro
ESCRT assembly domain
Helix hairpin bin domain superfamily
Modifier of rudimentary, Modr

Ortholog

Displaying entries **11 - 20** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	100027110	MONDO26803
Equus caballus	100059152	HORSE05955
Ornithorhynchus anatinus	100084407	ORNAN17704
Pongo abelii	100172801	PONAB03127
Taeniopygia guttata	100219087	TAEGU26494
Oryctolagus cuniculus	100356920	RABIT14676
Callithrix jacchus	100385623	CALJA03880
Ailuropoda melanoleuca	100476764	AILME03087
Meleagris gallopavo	100539197	MELGA10519
Anolis carolinensis	100553392	ANOCA16858

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements