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Rho GTPase activating protein 17

Summary

Gene Symbol

ARHGAP17

Organism

Homo sapiens (human)

External Links

NCBI Gene

55114

PubChem

55114

Alliance of Genome Resources

HGNC:18239

Annotation

Keyword

Alternative splicing
Cytoplasm
GTPase activation
Membrane
Phosphoprotein
Reference proteome
SH3-binding
Tight junction

Proteins

Displaying 1 entry
UniProt	Protein Name
Q68EM7	Rho-type GTPase-activating protein 17 RhoGAP interacting with CIP4 homologs protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
actin filament organization	IEA
signal transduction	IEA
calcium-ion regulated exocytosis	IEA
regulation of actin cytoskeleton organization	IBA
regulation of Rac protein signal transduction	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction

negative regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction

negative regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction

negative regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	IDA
cytosol	IBA
plasma membrane	IDA
plasma membrane	IBA
bicellular tight junction	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IBA
protein binding	IPI	21481793 25416956 28514442 32296183 33961781 35271311
SH3 domain binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

SH3 domain binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rho GTPase-activating protein 17

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
regulation of Rac protein signal transduction
regulation of actin cytoskeleton organization

Displaying **all 5** entries
InterPro
AH/BAR domain superfamily
BAR domain
Rho GTPase activation protein
Rho GTPase-activating protein 17/44/SH3BP1-like
Rho GTPase-activating protein domain

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	23616	FB:FBgn0038747
Xenopus tropicalis	55114	Xenbase:XB-GENE-981776
Rattus norvegicus	63994		RATNO17852
Mus musculus	70497	Xenbase:XB-GENE-981776	MOUSE56865
Drosophila melanogaster	216831	FB:FBgn0038747
Canis lupus familiaris	489964		CANLF16464
Bos taurus	504245		BOVIN20480
Macaca mulatta	701988		MACMU27031
Monodelphis domestica	100014519		MONDO29428
Ornithorhynchus anatinus	100074479		ORNAN16512