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ubiquitin like modifier activating enzyme 6

Summary

Gene Symbol

UBA6

Organism

Homo sapiens (human)

External Links

NCBI Gene

55236

PubChem

55236

Alliance of Genome Resources

HGNC:25581

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Ligase
Phosphoprotein
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
A0AVT1	Monocyte protein 4 Ubiquitin-activating enzyme E1-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IMP	17889673
ubiquitin-dependent protein catabolic process	IBA
cellular response to DNA damage stimulus	IBA
DNA damage response	IBA
learning	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

locomotory behavior

developmental process [inference]

anatomical structure development [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm	IDA
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
thiosulfate sulfurtransferase activity
ubiquitin activating enzyme activity	IBA
protein binding	IPI	17889673 25416956 25422469
ATP binding	IEA
nucleotidyltransferase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

transferase activity, transferring sulphur-containing groups [inference]

sulfurtransferase activity [inference]

thiosulfate sulfurtransferase activity

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

ubiquitin-like modifier activating enzyme activity [inference]

catalytic activity, acting on a protein [inference]

ubiquitin-like modifier activating enzyme activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ubiquitin-like modifier activating enzyme activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin activating enzyme

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
ATP binding
ligase activity
nucleotide binding
protein ubiquitination
ubiquitin activating enzyme activity

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InterPro
THIF-type NAD/FAD binding fold
ThiF/MoeB/HesA family
Ubiquitin-activating enzyme E1, C-terminal domain superfamily
Ubiquitin-activating enzyme E1, C-terminal
Ubiquitin-activating enzyme E1, Cys active site
Ubiquitin-activating enzyme E1, FCCH domain superfamily
Ubiquitin-activating enzyme E1, FCCH domain
Ubiquitin-activating enzyme E1, SCCH domain
Ubiquitin-activating enzyme E1, four-helix bundle
Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	55236	Xenbase:XB-GENE-1012392
Mus musculus	231380	Xenbase:XB-GENE-1012392	MOUSE44977
Rattus norvegicus	305268		RATNO07700
Pan troglodytes	461294		PANTR33884
Canis lupus familiaris	475160		CANLF03433
Bos taurus	518834		BOVIN31571
Danio rerio	567370		DANRE18107
Macaca mulatta	711751		MACMU37257
Monodelphis domestica	100012977		MONDO26157
Equus caballus	100067272		HORSE31752