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nei like DNA glycosylase 3

Summary

Gene Symbol

NEIL3

Aliases

FLJ10858
FPG2
ZGRF3
hFPG2
hNEI3
zinc finger, GRF-type containing 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

55247

HGNC

24573

PubChem

55247

Alliance of Genome Resources

HGNC:24573

Annotation

Keyword

3D-structure
Chromosome
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Phosphoprotein
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TAT5	DNA glycosylase FPG2 DNA glycosylase/AP lyase Neil3 Endonuclease VIII-like 3 Nei-like protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
single strand break repair	IDA	19170771
base-excision repair	ISS
base-excision repair	IDA	23755964
base-excision repair	IBA
base-excision repair, AP site formation	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

DNA modification [inference]

depurination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA	12433996
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
chromosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
bubble DNA binding	ISS
damaged DNA binding	ISS
double-stranded DNA binding	ISS
single-stranded DNA binding	IDA	19170771
DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	19170771

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

MCM complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

bubble DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease 8-like 3

Functional Category

H: Coenzyme transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
DNA repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair
catalytic activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
damaged DNA binding
endonuclease activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
hydrolase activity

Displaying **all 9** entries
InterPro
DNA glycosylase/AP lyase, H2TH DNA-binding
DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site
Formamidopyrimidine-DNA glycosylase, catalytic domain
MutM-like, N-terminal
Small ribosomal subunit protein uS13-like, H2TH
Zinc finger, DNA glycosylase/AP lyase-type
Zinc finger, GRF-type
Zinc finger, RanBP2-type superfamily
Zinc finger, RanBP2-type

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	55247	Xenbase:XB-GENE-1001611
Mus musculus	234258	Xenbase:XB-GENE-1001611	MOUSE58217
Rattus norvegicus	290729		RATNO11893
Pan troglodytes	471359		PANTR34859
Canis lupus familiaris	475639		CANLF04806
Danio rerio	492463		DANRE07885
Bos taurus	515343		BOVIN21889
Macaca mulatta	699618		MACMU37337
Monodelphis domestica	100017570		MONDO26309
Equus caballus	100060702		HORSE25059