GlyCosmos Portal

prolylcarboxypeptidase

Summary

Gene Symbol

PRCP

Organism

Homo sapiens (human)

External Links

NCBI Gene

5547

PubChem

5547

Alliance of Genome Resources

HGNC:9344

Annotation

Keyword

3D-structure
Alternative splicing
Carboxypeptidase
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P42785	Angiotensinase C Lysosomal carboxypeptidase C Proline carboxypeptidase Prolylcarboxypeptidase
B7Z7Q6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma kallikrein-kinin cascade	IEA
angiogenesis involved in wound healing	IBA
proteolysis	IEA
regulation of blood vessel endothelial cell migration	IBA
regulation of reactive oxygen species metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein maturation [inference]

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein maturation [inference]

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein maturation [inference]

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein maturation [inference]

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in wound healing

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of thyroid hormone mediated signaling pathway

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

regulation of blood vessel endothelial cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of thyroid hormone mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of thyroid hormone mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

regulation of blood vessel endothelial cell migration

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ficolin-1-rich granule membrane	TAS
basal part of cell	IEA
intracellular membrane-bounded organelle	IDA
plasma membrane	TAS
azurophil granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

basal part of cell

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20517885
serine-type carboxypeptidase activity	IEA
dipeptidyl-peptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity

dipeptidyl-peptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity

dipeptidyl-peptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type exopeptidase activity

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3454	brain infarction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35316		FB:FBgn0032864
Mus musculus	72461		MGI:1919711	MOUSE53779
Caenorhabditis elegans	176086		WB:WBGene00003956
Caenorhabditis elegans	176111		WB:WBGene00022801
Rattus norvegicus	293118		RGD:1307842	RATNO18785
Danio rerio	436967		ZFIN:ZDB-GENE-040718-447	DANRE08667
Pan troglodytes	451453	9598_0:0031e8		PANTR03946
Canis lupus familiaris	476788			CANLF08219
Bos taurus	534927			BOVIN22853
Equus caballus	100061830			HORSE39552

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements