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myotubularin related protein 8

Summary

Gene Symbol

MTMR8

Aliases

FLJ20126

Organism

Homo sapiens (human)

External Links

NCBI Gene

55613

HGNC

16825

KEGG Gene ID

hsa:55613

PubChem

55613

Alliance of Genome Resources

HGNC:16825

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Hydrolase
Lipid metabolism
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96EF0	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Phosphatidylinositol-3-phosphate phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphatidylinositol dephosphorylation	IBA IDA	22647598
negative regulation of autophagy	IPI	22647598
regulation of macroautophagy	IMP	32915229

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-containing complex	IDA	22647598
nuclear envelope	IBA IDA	16787938
cytosol	TAS
cytoplasm	IBA IDA	16787938

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 16787938 22647598 27880917 28514442 29892012 31515488 33961781
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA
phosphatidylinositol-3-phosphate phosphatase activity	IBA IDA	22647598
phosphatidylinositol-3,5-bisphosphate phosphatase activity	IBA IDA	22647598

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,5-bisphosphate phosphatase activity

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

phosphatidylinositol monophosphate phosphatase activity [inference]

phosphatidylinositol-3-phosphate phosphatase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myotubularin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
dephosphorylation

Displaying **all 5** entries
InterPro
Myotubularin family
Myotubularin-like, phosphatase domain
PH-like domain superfamily
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase-like

KEGG BRITE Database

Orthology

K18083

Name

myotubularin-related protein 6/7/8 [EC:3.1.3.64 3.1.3.95]

References

16847315

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)

Enzyme

3.1.3.95

PMID

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

Enzyme

3.1.3.64

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111225	centronuclear myopathy X-linked	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:14717	centronuclear myopathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37707		FB:FBgn0028497
Caenorhabditis elegans	176757		WB:WBGene00003478
Danio rerio	393365		ZFIN:ZDB-GENE-040426-1016	DANRE35984
Pan troglodytes	465670	9598_0:0056f9		PANTR46148
Macaca mulatta	708037			MACMU47116
Saccharomyces cerevisiae S288C	853574		SGD:S000003871
Monodelphis domestica	100028310			MONDO00553
Equus caballus	100054675			HORSE43394
Taeniopygia guttata	100231272			TAEGU22727
Oryctolagus cuniculus	100355823			RABIT13550

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024