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MIRAGE
protein kinase AMP-activated catalytic subunit alpha 1
Summary
- Gene Symbol
-
- PRKAA1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Autophagy
- Biological rhythms
- Cholesterol biosynthesis
- Chromatin regulator
- Cytoplasm
- Fatty acid biosynthesis
- Glycoprotein
- Host-virus interaction
- Magnesium
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Transcription regulation
- Ubl conjugation
- Wnt signaling pathway
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13131 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to hypoxia | ||
| positive regulation of T cell mediated immune response to tumor cell | ||
| glucose metabolic process | ||
| chromatin remodeling | ||
| protein phosphorylation |
GO Hierarchy
- rhythmic process
- response to activity
- regulation of circadian rhythm
- regulation of vesicle-mediated transport
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cellular component biogenesis [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular localization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromatin binding | ||
| protein kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| 3-phosphoinositide-dependent protein kinase activity |
GO Hierarchy
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
- tau-protein kinase activity
- protein serine kinase activity
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
- tau-protein kinase activity
- protein serine kinase activity
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
- tau-protein kinase activity
- protein serine kinase activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity
protein serine/threonine kinase activity
histone kinase activity [inference]
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity
protein serine/threonine kinase activity
histone kinase activity [inference]
catalytic activity, acting on a protein [inference]
protein kinase activity
protein serine/threonine kinase activity
histone kinase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Serine/threonine-protein kinase, active site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12858 | Huntington's disease | |
| DOID:1612 | breast cancer | |
| DOID:219 | colon cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5562 | Xenbase:XB-GENE-946195 | ||
| 5563 | SGD:S000002885 | ||
| 65248 | Xenbase:XB-GENE-946195 | RATNO23085 | |
| 105787 | Xenbase:XB-GENE-946195 | MOUSE15021 | |
| 108079 | SGD:S000002885 | ||
| 540404 | BOVIN16009 | ||
| 695558 | MACMU39802 | ||
| 696436 | MACMU39802 | ||
| 100001198 | DANRE37218 | ||
| 100013711 | MONDO18309 |
