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NPL4 homolog, ubiquitin recognition factor

Summary

Gene Symbol

NPLOC4

Organism

Homo sapiens (human)

External Links

NCBI Gene

55666

PubChem

55666

Alliance of Genome Resources

HGNC:18261

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chaperone
Cytoplasm
Direct protein sequencing
Endoplasmic reticulum
Nucleus
Reference proteome
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TAT6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IMP	26471729
ubiquitin-dependent protein catabolic process	IBA
Golgi organization	ISS	11574150
retrograde protein transport, ER to cytosol	ISO
retrograde protein transport, ER to cytosol	IMP	25660456

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of RIG-I signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of RIG-I signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleus	HDA	21630459
nucleoplasm	TAS
endoplasmic reticulum	ISS	11574150
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

UFD1-NPL4 complex

membrane protein complex [inference]

VCP-NPL4-UFD1 AAA ATPase complex

endoplasmic reticulum protein-containing complex [inference]

VCP-NPL4-UFD1 AAA ATPase complex

cellular anatomical entity [inference]

membrane [inference]

nuclear outer membrane-endoplasmic reticulum membrane network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11574150 17070805 18775313 20414249 21645854 26471729 32296183 32814053 33961781 35271311
zinc ion binding	IEA
ubiquitin protein ligase binding	IBA
K48-linked polyubiquitin modification-dependent protein binding	IEA
ubiquitin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

ATPase binding

ubiquitin-like protein binding [inference]

ubiquitin binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein NPL4

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ubiquitin binding
ubiquitin protein ligase binding

Displaying **all 6** entries
InterPro
MPN domain
NPL4, zinc-binding putative
Nuclear pore localisation protein NPL4, C-terminal
Nuclear pore localisation protein Npl4, ubiquitin-like domain
Nuclear protein localization protein 4
Ubiquitin-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	55666	Xenbase:XB-GENE-958208
Rattus norvegicus	140639		RATNO02024
Mus musculus	217365		MOUSE04975
Danio rerio	327447		DANRE04706
Pan troglodytes	454960		PANTR15669
Canis lupus familiaris	483363		CANLF18354
Bos taurus	508519		BOVIN13782
Macaca mulatta	713927		MACMU15927
Ornithorhynchus anatinus	100090055		ORNAN00200
Taeniopygia guttata	100224052		TAEGU07063

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements