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SMC5-SMC6 complex localization factor 2

Summary

Gene Symbol

SLF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

55719

PubChem

55719

Alliance of Genome Resources

HGNC:17814

Annotation

Keyword

3D-structure
Alternative splicing
DNA repair
Disease variant
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IX21	Smc5/6 localization factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	NAS	16810316
cellular response to DNA damage stimulus	IDA	25931565
DNA damage response	IDA	25931565
cellular response to DNA damage stimulus	IBA
DNA damage response	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin looping

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of telomere maintenance

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of telomere maintenance

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of telomere maintenance

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of telomere maintenance

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of protein-containing complex assembly

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of telomere maintenance

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of protein-containing complex assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion [inference]

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of telomere maintenance

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of protein-containing complex assembly

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion [inference]

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	NAS	17589526
chromatin	IDA	24561620
nucleus	IDA	24561620
nucleus	IBA
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

catalytic complex [inference]

transferase complex [inference]

SUMO ligase complex [inference]

Smc5-Smc6 complex

cellular anatomical entity [inference]

nucleoplasm

nuclear body [inference]

PML body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

site of DNA damage [inference]

site of double-strand break

chromosomal region [inference]

chromosome, telomeric region

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25931565 26496610 32296183 32389690 33961781 36373674
ubiquitin protein ligase binding	IPI	25931565
protein-containing complex binding	IPI	25931565

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SMC5-SMC6 complex localization factor 2

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
positive regulation of double-strand break repair
protein localization to site of double-strand break

Displaying **all 2** entries
InterPro
Coiled-coil SMC6 And NSE5 INteracting (CANIN) domain
FAM178 family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080688	mosaic variegated aneuploidy syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	55719	Xenbase:XB-GENE-483436
Xenopus tropicalis	57138	Xenbase:XB-GENE-483436
Xenopus tropicalis	57468	Xenbase:XB-GENE-483436
Xenopus tropicalis	171373	Xenbase:XB-GENE-483436
Mus musculus	226151		MOUSE26089
Pan troglodytes	450860		PANTR01370
Rattus norvegicus	499360		RATNO18800
Bos taurus	541239		BOVIN21370
Canis lupus familiaris	612816		CANLF11395
Equus caballus	100070315		HORSE17138

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements