GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cardiomyopathy
Cataract
Disease variant
Kinase
Lipid metabolism
Mitochondrion inner membrane
Primary mitochondrial disease
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53H12	Multiple substrate lipid kinase
A4D1U5	Multiple substrate lipid kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein insertion into mitochondrial inner membrane	IDA	28712724 28712726 32901109
ceramide biosynthetic process	IBA
glycerolipid metabolic process	IEA
lipid phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

lipid phosphorylation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

lipid phosphorylation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of localization [inference]

transport [inference]

mitochondrial transport [inference]

protein insertion into mitochondrial inner membrane

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
TIM22 mitochondrial import inner membrane insertion complex	IDA IPI	28712724 28712726 32901109
mitochondrial intermembrane space	IDA	28712724 28712726
mitochondrion	IBA IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM22 mitochondrial import inner membrane insertion complex

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM22 mitochondrial import inner membrane insertion complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

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GO Term	Evidence Code	PMID
dihydroceramide kinase activity	IEA
acylglycerol kinase activity	IBA IDA	15939762
ATP-dependent diacylglycerol kinase activity	IBA IDA	15939762
ceramide kinase activity	IBA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

acylglycerol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000006530

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K09881

Name

acylglycerol kinase [EC:2.7.1.94]

References

15252046

Rhea

RHEA:17929

ATP + an N-acylsphing-4-enine

H⁺ + ADP + an N-acylsphing-4-enine 1-phosphate

Enzyme

2.7.1.138

PMID

RHEA:10272

a 1,2-diacyl-sn-glycerol + ATP

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.7.1.107

PMID

15939762

RHEA:19293

a monoacylglycerol + ATP

H⁺ + ADP + monoacyl-sn-glycero-3-phosphate

Enzyme

2.7.1.94

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of **131** in total

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DO ID	Disease Name	Source
DOID:0110251	cataract 15 multiple types	DisGeNET
DOID:0110252	cataract 37	DisGeNET
DOID:0110253	cataract 14 multiple types	DisGeNET
DOID:0110254	cataract 25	DisGeNET
DOID:0110255	cataract 5 multiple types	DisGeNET
DOID:0110256	cataract 21 multiple types	DisGeNET
DOID:0110257	cataract 24	DisGeNET
DOID:0110258	cataract 10 multiple types	DisGeNET
DOID:0110259	cataract 43	DisGeNET
DOID:0110260	cataract 7	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 40 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000486	Strabismus
HP:0000501	Glaucoma
HP:0000512	Abnormal electroretinogram
HP:0000518	Cataract
HP:0000519	Developmental cataract
HP:0000545	Myopia
HP:0000639	Nystagmus
HP:0000938	Osteopenia
HP:0001131	Corneal dystrophy

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:212350	Sengers syndrome
OMIM:614691	cataract 38
ORPHA:1369	Sengers syndrome

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002516
Gene Name: acylglycerol kinase

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175732	WB:WBGene00018674
Drosophila melanogaster	326168	FB:FBgn0260750
Callorhinchus milii	103186213		CALMI34103
Danio rerio	334270	ZFIN:ZDB-GENE-030131-6202	DANRE14288
Astyanax mexicanus	103035268		ASTMX10268
Ictalurus punctatus	108264378		ICTPU28239
Electrophorus electricus	113573608		ELEEL11835
Salmo salar	106573186		SALSA48626
Salmo trutta	115152226		SALTR114585
Salmo trutta	115197424		SALTR13179

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements