GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cardiomyopathy
Cataract
Disease variant
Kinase
Lipid metabolism
Mitochondrion inner membrane
Primary mitochondrial disease
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53H12	Multiple substrate lipid kinase
A4D1U5	Multiple substrate lipid kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein insertion into mitochondrial inner membrane	IDA	28712724 28712726 32901109
ceramide biosynthetic process	IBA
glycerolipid metabolic process	IEA
lipid phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

lipid phosphorylation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

lipid phosphorylation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of localization [inference]

transport [inference]

mitochondrial transport [inference]

protein insertion into mitochondrial inner membrane

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial inner membrane

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
mitochondrial inner membrane	IDA	28712724 28712726 32901109
cytosol
mitochondrial membrane	IDA	15939762 16269826
mitochondrial outer membrane

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM22 mitochondrial import inner membrane insertion complex

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM22 mitochondrial import inner membrane insertion complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

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GO Term	Evidence Code	PMID
dihydroceramide kinase activity	IEA
acylglycerol kinase activity	IBA IDA	15939762
ATP-dependent diacylglycerol kinase activity	IBA IDA	15939762
ceramide kinase activity	IBA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

acylglycerol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000006530

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K09881

Name

acylglycerol kinase [EC:2.7.1.94]

References

15252046

Rhea

RHEA:17929

ATP + an N-acylsphing-4-enine

H⁺ + ADP + an N-acylsphing-4-enine 1-phosphate

Enzyme

2.7.1.138

PMID

RHEA:10272

a 1,2-diacyl-sn-glycerol + ATP

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.7.1.107

PMID

15939762

RHEA:19293

a monoacylglycerol + ATP

H⁺ + ADP + monoacyl-sn-glycero-3-phosphate

Enzyme

2.7.1.94

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **131** in total

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DO ID	Disease Name	Source
DOID:0050557	congenital muscular dystrophy	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET
DOID:0050729	Chanarin-Dorfman syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060336	3-methylglutaconic aciduria	DisGeNET
DOID:0080132	Sengers syndrome	DisGeNET Alliance of Genome Resources
DOID:0080326	familial hypertrophic cardiomyopathy	DisGeNET
DOID:0080335	mitochondrial DNA depletion syndrome 12b	DisGeNET
DOID:0110227	cataract 32 multiple types	DisGeNET
DOID:0110228	cataract 8 multiple types	DisGeNET

The Human Phenotype Ontology

Displaying entries **21 - 30** of 40 in total

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HPO ID	HPO Term
HP:0002092	Pulmonary arterial hypertension
HP:0002093	Respiratory insufficiency
HP:0002151	Increased circulating lactate concentration
HP:0003128	Lactic acidosis
HP:0003198	Myopathy
HP:0003324	Generalized muscle weakness
HP:0003388	Easy fatigability
HP:0003535	3-Methylglutaconic aciduria
HP:0003546	Exercise intolerance
HP:0003577	Congenital onset

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:212350	Sengers syndrome
OMIM:614691	cataract 38
ORPHA:1369	Sengers syndrome

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002516
Gene Name: acylglycerol kinase

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175732	WB:WBGene00018674
Drosophila melanogaster	326168	FB:FBgn0260750
Callorhinchus milii	103186213		CALMI34103
Danio rerio	334270	ZFIN:ZDB-GENE-030131-6202	DANRE14288
Astyanax mexicanus	103035268		ASTMX10268
Ictalurus punctatus	108264378		ICTPU28239
Electrophorus electricus	113573608		ELEEL11835
Salmo salar	106573186		SALSA48626
Salmo trutta	115152226		SALTR114585
Salmo trutta	115197424		SALTR13179

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements