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transmembrane protein 30A

Summary

Gene Symbol

TMEM30A

Organism

Homo sapiens (human)

External Links

NCBI Gene

55754

PubChem

55754

Alliance of Genome Resources

HGNC:16667

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Lipid transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NV96	P4-ATPase flippase complex beta subunit TMEM30A Transmembrane protein 30A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
aminophospholipid transport	IDA	20510206
protein localization to endosome	IMP	21914794
aminophospholipid translocation	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endosome

transmembrane transport [inference]

xenobiotic transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endosome

establishment of localization [inference]

transport [inference]

xenobiotic transport [inference]

xenobiotic transmembrane transport

transmembrane transport [inference]

xenobiotic transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

aminophospholipid transport

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

aminophospholipid transport

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

nitrogen compound transport [inference]

aminophospholipid transport

aminophospholipid translocation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endosome

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of phospholipid translocation

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of phospholipid translocation

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of phospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	20510206 20961850 25947375 26567335
late endosome membrane	IDA	26567335
specific granule membrane	TAS
endoplasmic reticulum	IBA IDA	21914794
early endosome membrane	IDA	31571211

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

transport vesicle membrane

secretory granule membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

endosome membrane [inference]

transport vesicle membrane

secretory granule membrane [inference]

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19731236 20947505 20961850 21914794 25239307 25947375 30086173 31397519 31416931 31571211 32172343 32296183 32814053 33961781
aminophospholipid flippase activity	IDA	20510206
structural molecule activity	IDA	32493773

GO Hierarchy

molecular function

structural molecule activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

aminophospholipid flippase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

aminophospholipid flippase activity

binding [inference]

protein binding

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

aminophospholipid flippase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ALA-interacting subunit

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
CDC50/LEM3 family

Ortholog

Displaying entries **11 - 20** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Bos taurus	505797			BOVIN35351
Macaca mulatta	717907			MACMU34574
Saccharomyces cerevisiae S288C	850456		SGD:S000000690
Saccharomyces cerevisiae S288C	855393		SGD:S000005267
Saccharomyces cerevisiae S288C	855784		SGD:S000005331
Monodelphis domestica	100021913			MONDO10332
Ornithorhynchus anatinus	100080887			ORNAN10569
Sus scrofa	100154255			PIGXX13955
Pongo abelii	100169735	9601_0:001dca		PONAB31771
Taeniopygia guttata	100232609			TAEGU20934

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Last updated: December 9, 2024