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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
N-glycanase 1
Summary
- Gene Symbol
-
- NGLY1
- Aliases
-
- FLJ11005
- PNG-1
- PNG1
- peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
- peptide:N-glycanase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cytoplasm
- Hydrolase
- Metal-binding
- Phosphoprotein
- Reference proteome
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q96IV0 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein deglycosylation | ||
| protein folding |
|
|
| glycoprotein catabolic process |
GO Hierarchy
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| metal ion binding | ||
| protein binding | ||
| peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1143 | exotropia | |
| DOID:11476 | osteoporosis | |
| DOID:11541 | recurrent corneal erosion | |
| DOID:11832 | visual epilepsy | |
| DOID:11853 | monocular exotropia | |
| DOID:12859 | choreatic disease | |
| DOID:13353 | diffuse interstitial keratitis | |
| DOID:1389 | polyneuropathy | |
| DOID:14402 | critical illness polyneuropathy | |
| DOID:1443 | cerebral degeneration |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0004305 | Involuntary movements |
| HP:0004325 | Decreased body weight |
| HP:0004349 | Reduced bone mineral density |
| HP:0005484 | Secondary microcephaly |
| HP:0005543 | Reduced protein C activity |
| HP:0006254 | Elevated circulating alpha-fetoprotein concentration |
| HP:0007021 | Pain insensitivity |
| HP:0007141 | Sensorimotor neuropathy |
| HP:0007957 | Corneal opacity |
| HP:0008151 | Prolonged prothrombin time |
| Disease ID | Disease Name |
|---|---|
| ORPHA:404454 |
|
| OMIM:615273 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101053768 | SAIBB26182 | ||
| 101974603 | ICTTR03701 | ||
| 101616329 | JACJA12819 | ||
| 102435206 | MYOLU04334 | ||
| 117036934 | RHIFE16156 | ||
| 100228315 | TAEGU17429 | ||
| 101814726 | FICAL00636 | ||
| 103241778 | CHLSB04929 | ||
| 108543075 | RHIBE19666 | ||
| 104658078 | RHIRO18892 |
