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RIO kinase 2

Summary

Gene Symbol

RIOK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

55781

PubChem

55781

Alliance of Genome Resources

HGNC:18999

JoGo

RIOK2

TogoVar

RIOK2

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell cycle
Cytoplasm
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Ribosome biogenesis
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BVS4	RIO kinase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
regulation of mitotic metaphase/anaphase transition	IMP	21880710
maturation of SSU-rRNA	IMP	19564402
maturation of SSU-rRNA	IBA
ribosomal small subunit biogenesis	IMP	19564402

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

ribosomal small subunit biogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal small subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal small subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribonucleoprotein complex localization [inference]

positive regulation of ribonucleoprotein complex localization [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal small subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

positive regulation of ribonucleoprotein complex localization [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

positive regulation of ribonucleoprotein complex localization [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition

regulation of cell cycle process [inference]

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition

regulation of cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal small subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribonucleoprotein complex localization [inference]

positive regulation of ribonucleoprotein complex localization [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

regulation of ribosomal small subunit export from nucleus [inference]

positive regulation of ribosomal small subunit export from nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
cytoplasm	IMP	19564402
cytosol	TAS
cytosol	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

preribosome [inference]

preribosome, small subunit precursor

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IBA
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA
AMP-activated protein kinase activity	IEA
eukaryotic translation initiation factor 2alpha kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
kinase activity
maturation of SSU-rRNA
nucleotide binding
phosphorylation
protein phosphorylation
transferase activity

Displaying **all 7** entries
InterPro
Protein kinase-like domain superfamily
RIO kinase, conserved site
RIO kinase
RIO2 kinase winged helix domain, N-terminal
Serine/threonine-protein kinase Rio2
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements