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LMBR1 domain containing 1

Summary

Gene Symbol

LMBRD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

55788

PubChem

55788

Alliance of Genome Resources

HGNC:23038

Annotation

Keyword

Alternative splicing
Cell membrane
Cobalamin
Cytoplasmic vesicle
Endocytosis
Endoplasmic reticulum
Gastrulation
Glycoprotein
Host-virus interaction
Lysosome
Phosphoprotein
Reference proteome
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NUN5	HDAg-L-interacting protein NESI LMBR1 domain-containing protein 1 Nuclear export signal-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
gastrulation	ISS
insulin receptor internalization	ISS
protein localization to lysosome	IDA	27456980
protein localization to lysosome	IBA
clathrin-dependent endocytosis	ISS

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	TAS
lysosomal membrane	IDA	27456980
lysosomal membrane	IBA
endoplasmic reticulum membrane	IDA	27456980
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
insulin receptor binding	IEA
protein binding	IPI	25535791 27456980 28572511 32296183 33845046
cobalamin binding	IEA
clathrin heavy chain binding	ISS
AP-2 adaptor complex binding	ISS

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding

signaling receptor binding [inference]

insulin receptor binding

clathrin binding [inference]

clathrin heavy chain binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysosomal cobalamin transporter

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cobalamin binding
protein localization to lysosome

Displaying 1 entry
InterPro
LMBR1-like membrane protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050717	methylmalonic aciduria and homocystinuria type cblF	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 77 in total

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Species	Gene ID	Orthologous MAtrix
Myotis lucifugus	102441822	MYOLU05501
Pelodiscus sinensis	102453756	PELSI13694
Callorhinchus milii	103185611	CALMI32656
Chlorocebus sabaeus	103243937	CHLSB06179
Carlito syrichta	103261367	CARSF22464
Oryctolagus cuniculus	103349790	RABIT02572
Ursus maritimus	103657465	URSMA11226
Serinus canaria	103822688	SERCA02707
Rhinopithecus roxellana	104668865	RHIRO05234
Mandrillus leucophaeus	105535821	MANLE39748

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements