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sodium voltage-gated channel beta subunit 3

Summary

Gene Symbol

SCN3B

Organism

Homo sapiens (human)

External Links

NCBI Gene

55800

PubChem

55800

Alliance of Genome Resources

HGNC:20665

Annotation

Keyword

3D-structure
Atrial fibrillation
Brugada syndrome
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Sodium channel
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NY72

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
sodium ion transport	NAS	10688874
cardiac muscle contraction	IMP	20042427 21051419
atrial cardiac muscle cell action potential	IMP	21051419
cardiac muscle cell action potential involved in contraction	IMP	21051419
membrane depolarization during action potential	IDA IMP	20042427 20226894 21051419

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

positive regulation of sodium ion transport

regulation of sodium ion transmembrane transport [inference]

regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

regulation of sodium ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

regulation of sodium ion transmembrane transporter activity

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

SA node cell action potential

regulation of membrane depolarization [inference]

membrane depolarization

membrane depolarization during action potential

membrane depolarization during cardiac muscle cell action potential

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of sodium ion transmembrane transporter activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	NAS	10688874
voltage-gated sodium channel complex	IBA IDA TAS	20042427 21051419 21895525 24567321
plasma membrane	IDA	24567321
Z disc	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

Z disc

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 32296183 33961781
sodium channel regulator activity	IDA IMP	20042427 20226894 21051419
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA
transmembrane transporter binding	IBA IPI	20042427
sodium channel inhibitor activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

binding [inference]

protein binding

transmembrane transporter binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

sodium channel regulator activity

sodium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sodium channel subunit beta-3

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
monoatomic ion transport
regulation of heart rate by cardiac conduction
sodium channel activity
sodium channel regulator activity
sodium ion transmembrane transport
transmembrane transporter binding
ventricular cardiac muscle cell action potential

Displaying **all 6** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Sodium channel subunit beta-1/beta-3

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110224	Brugada syndrome 7	Alliance of Genome Resources
DOID:4724	brain edema	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	235281		MGI:1918882	MOUSE61718
Rattus norvegicus	245956		RGD:621657	RATNO40504
Xenopus laevis	446511		Xenbase:XB-GENE-955446
Pan troglodytes	466810	9598_0:00306c		PANTR04612
Xenopus tropicalis	496752		Xenbase:XB-GENE-955441
Bos taurus	540925			BOVIN06662
Danio rerio	563935		ZFIN:ZDB-GENE-070920-2	DANRE08247
Canis lupus familiaris	610239			CANLF15170
Macaca mulatta	714673			MACMU10909
Monodelphis domestica	100030470			MONDO25492