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MIRAGE

VPS11 core subunit of CORVET and HOPS complexes

Summary

Gene Symbol

VPS11

Organism

Homo sapiens (human)

External Links

NCBI Gene

55823

PubChem

55823

Alliance of Genome Resources

HGNC:14583

JoGo

VPS11

TogoVar

VPS11

Annotation

Keyword

Acetylation
Autophagy
Coiled coil
Cytoplasmic vesicle
Disease variant
Dystonia
Endosome
Leukodystrophy
Lysosome
Membrane
Methylation
Nucleotide-binding
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H270	RING finger protein 108
B7Z879

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	IEA
vesicle docking involved in exocytosis	IBA
autophagy	IEA
endosome organization	IBA
vacuole organization	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization

vesicle organization [inference]

vesicle fusion [inference]

endosomal vesicle fusion

endosome organization

organelle fusion

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

exocytic process [inference]

vesicle docking involved in exocytosis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

organelle localization [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of intracellular estrogen receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of vesicle-mediated transport [inference]

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

regulation of establishment of protein localization to mitochondrion [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of intracellular estrogen receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of intracellular estrogen receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of organelle assembly

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular steroid hormone receptor signaling pathway [inference]

negative regulation of intracellular estrogen receptor signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of organelle assembly

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

regulation of establishment of protein localization to mitochondrion [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

regulation of vesicle-mediated transport [inference]

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
lysosome	IDA	11382755 21148287 21802320
lysosomal membrane	HDA	17897319
endosome	IDA	20682791
endosome	IBA
early endosome	IDA	21148287

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

HOPS complex

vesicle tethering complex [inference]

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

endocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

endocytic vesicle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein binding	IPI	11382755 21148287 22493164 23901104 25266290 25416956 25500191 26496610 28325809 28514442 29778605 32296183 32814053 33422265 33961781 35271311
zinc ion binding	IEA
protein domain specific binding	IPI	21148287
syntaxin binding	IDA	11382755

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding

protein domain specific binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vacuolar protein

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
endosome organization
metal ion binding
organelle fusion
protein-macromolecule adaptor activity
vesicle docking involved in exocytosis

Displaying **all 9** entries
InterPro
Armadillo-type fold
Clathrin, heavy chain/VPS, 7-fold repeat
Tetratricopeptide-like helical domain superfamily
Vacuolar protein sorting protein 11, C-terminal
Vacuolar protein sorting-associated protein 11
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060796	hypomyelinating leukodystrophy 12	Alliance of Genome Resources
DOID:0060939	dystonia 32	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025