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Standards Ontologies Notations
Guidelines
MIRAGE
CF transmembrane conductance regulator

Summary
Gene Symbol
  • cftr
Organism
Danio rerio (zebrafish)
NCBI Gene
559080
PubChem
559080
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Cell membrane
  • Chloride channel
  • Endoplasmic reticulum
  • Endosome
  • Glycoprotein
  • Isomerase
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q1LX78
  • ATP-binding cassette sub-family C member 7
  • Channel conductance-controlling ATPase
  • cAMP-dependent chloride channel
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 26 in total
GO Term Evidence Code PMID
respiratory burst involved in defense response
monoatomic ion transport
ion transport
chloride transport
heart development
GO Hierarchy
Displaying entries 1 - 5 of 14 in total
GO Term Evidence Code PMID
endosome
endoplasmic reticulum
endoplasmic reticulum membrane
cytosol
plasma membrane
GO Hierarchy
Displaying entries 1 - 5 of 21 in total
GO Term Evidence Code PMID
nucleotide binding
DNA clamp loader activity
chloride channel activity
chloride channel activity
chloride channel activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
ABC
Functional Category
  • J: Translation, ribosomal structure and biogenesis
  • K: Transcription
  • T: Signal transduction mechanisms
Displaying all 3 entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding
Displaying all 6 entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase
Alliance of Genome Resources
Expression
Displaying all 2 entries
Location References
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:1485 cystic fibrosis
DOID:9351 diabetes mellitus
Ortholog
Displaying entries 1 - 10 of 88 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
1080 Xenbase:XB-GENE-853972 HUMAN90993
10257 FB:FBgn0263316
12638 Xenbase:XB-GENE-853972 MOUSE49101
24255 Xenbase:XB-GENE-853972 RATNO29396
47905 FB:FBgn0010549
89845 SGD:S000001811
281067 BOVIN27987
443347 SHEEP15466
463674 PANTR41247
492302 CANLF03852
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025