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Submissions

leucine rich repeat containing 8 VRAC subunit A

Summary

Gene Symbol

LRRC8A

Organism

Homo sapiens (human)

External Links

NCBI Gene

56262

PubChem

56262

Alliance of Genome Resources

HGNC:19027

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Chromosomal rearrangement
Direct protein sequencing
Disulfide bond
Glycoprotein
Ion channel
Leucine-rich repeat
Lysosome
Phosphoprotein
Reference proteome
Repeat
Spermatogenesis
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K1C7
Q8IWT6	Leucine-rich repeat-containing protein 8A Swelling protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
intracellular glucose homeostasis	ISS
response to osmotic stress	IMP	24725410 24790029
taurine transport	IEA
anion transport	IMP	24725410 24790029
positive regulation of myoblast differentiation	ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

B cell activation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

B cell activation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

signal transduction [inference]

intracellular signal transduction

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

chloride transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

B cell activation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress

response to abiotic stimulus [inference]

response to osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

chloride transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

alkanesulfonate transport [inference]

taurine transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

cyclic-GMP-AMP transmembrane import across plasma membrane

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transport [inference]

alkanesulfonate transport [inference]

taurine transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

taurine transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

sulfur compound transport [inference]

alkanesulfonate transport [inference]

taurine transport

import into cell [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	IDA	33139539
cytoplasm	IBA
plasma membrane	IBA IDA ISS TAS	24725410 24790029 33139539
membrane	HDA IDA	19946888 30095067
monoatomic ion channel complex	IBA IDA	24790029

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	24790029 28514442 33961781
monoatomic anion channel activity	IMP	24725410 24790029
identical protein binding	IPI	24790029 30095067 30127360
volume-sensitive anion channel activity	IBA IDA IMP ISS	26824658 29769723 30095067 33139539
cyclic-GMP-AMP transmembrane transporter activity	IDA	33171122

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity

volume-sensitive anion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity

volume-sensitive anion channel activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

guanine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

guanine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity

volume-sensitive anion channel activity

carbohydrate derivative transmembrane transporter activity [inference]

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080588	agammaglobulinemia 5	Alliance of Genome Resources
DOID:2583	agammaglobulinemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **121** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	56262	Xenbase:XB-GENE-1012024
Mus musculus	241296	Xenbase:XB-GENE-1012024	MOUSE32924
Rattus norvegicus	311846	Xenbase:XB-GENE-1012024	RATNO27504
Danio rerio	327642		DANRE21322
Pan troglodytes	464779		PANTR44993
Canis lupus familiaris	491309		CANLF19383
Bos taurus	505605		BOVIN03261
Danio rerio	557928		DANRE36441
Macaca mulatta	717074		MACMU11983
Monodelphis domestica	100012271		MONDO03794

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements