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MIRAGE
protein S

Summary
Gene Symbol
  • PROS1
Organism
Homo sapiens (human)
NCBI Gene
5627
PubChem
5627
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Cleavage on pair of basic residues
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Fibrinolysis
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Hydroxylation
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Thrombophilia
  • Zymogen
Proteins
Displaying all 3 entries
UniProt Protein Name
A0A0S2Z4K3
P07225
A0A0S2Z4L3
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
blood coagulation
fibrinolysis
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
growth arrest specific 6
Functional Category
  • G: Carbohydrate transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
Displaying 1 entry
Gene Ontology
calcium ion binding
Displaying entries 1 - 10 of 11 in total
InterPro
Coagulation factor-like, Gla domain superfamily
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Gamma-carboxyglutamic acid-rich (GLA) domain
Growth factor receptor cysteine-rich domain superfamily
Laminin G domain
Disease
Disease Ontology
Displaying all 4 entries
DO ID Disease Name Source
DOID:0111900 autosomal dominant thrombophilia due to protein S deficiency
DOID:0111905 autosomal recessive thrombophilia due to protein S deficiency
DOID:2451 protein S deficiency
DOID:3526 cerebral infarction
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025