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transient receptor potential cation channel subfamily V member 5

Summary

Gene Symbol

TRPV5

Organism

Homo sapiens (human)

External Links

NCBI Gene

56302

PubChem

56302

Alliance of Genome Resources

HGNC:3145

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Calcium channel
Calmodulin-binding
Cell membrane
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NQA5	Calcium transport protein 2 Epithelial calcium channel 1 Osm-9-like TRP channel 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
calcium ion homeostasis	ISS
calcium ion transmembrane transport	IDA TAS	18768590
calcium ion import across plasma membrane	IBA IDA	18768590
regulation of urine volume	ISS
calcium ion transport	ISS TAS	15665527

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of urine volume

Displaying **all 2** entries
GO Term	Evidence Code	PMID
apical plasma membrane	ISS
plasma membrane	IBA IDA TAS	15489237 18768590

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16763551
calmodulin binding	IEA
metal ion binding	IEA
calcium channel activity	IBA IDA ISS TAS	18768590

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding

calmodulin binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transient receptor potential cation channel subfamily V member

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 4** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ion transport domain
Transient receptor potential cation channel subfamily V

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:11714	gestational diabetes	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31621	FB:FBgn0086693
Drosophila melanogaster	39571	FB:FBgn0036414
Rattus norvegicus	116469	RGD:620636	RATNO31109
Caenorhabditis elegans	177117	WB:WBGene00003889
Caenorhabditis elegans	177506	WB:WBGene00003841
Caenorhabditis elegans	185101	WB:WBGene00003838
Caenorhabditis elegans	188314	WB:WBGene00003839
Mus musculus	194352	MGI:2429764	MOUSE47500
Takifugu rubripes	446000		TAKRU45870
Bos taurus	524365		BOVIN28631

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OrthoDB (Group)

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Acknowledgements