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gamma-glutamyl carboxylase

Summary

Gene Symbol

Ggcx

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56316

PubChem

56316

Alliance of Genome Resources

MGI:1927655

Annotation

Keyword

Acetylation
Disulfide bond
Endoplasmic reticulum
Lyase
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9QYC7	Gamma-glutamyl carboxylase Peptidyl-glutamate 4-carboxylase Vitamin K gamma glutamyl carboxylase
B2RS80	Gamma-glutamyl carboxylase Peptidyl-glutamate 4-carboxylase Vitamin K gamma glutamyl carboxylase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
peptidyl-glutamic acid carboxylation	IMP	17327402
vitamin K metabolic process	ISO
vitamin K metabolic process	IMP	37171959
vitamin K metabolic process	IBA
negative regulation of neurotransmitter secretion	IMP	25264202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

small molecule metabolic process [inference]

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin K metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

organic substance metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of testosterone biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of testosterone biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

negative regulation of developmental process [inference]

negative regulation of bone development

negative regulation of multicellular organismal process [inference]

negative regulation of bone development

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of bone development

regulation of multicellular organismal development [inference]

regulation of bone development [inference]

negative regulation of bone development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of testosterone biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of testosterone biosynthetic process

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of bone development

regulation of multicellular organismal development [inference]

regulation of bone development [inference]

negative regulation of bone development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA	17327402
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
gamma-glutamyl carboxylase activity	ISS	10893417
gamma-glutamyl carboxylase activity	ISO
gamma-glutamyl carboxylase activity	IDA	25264202
gamma-glutamyl carboxylase activity	IMP	17327402 25264202
gamma-glutamyl carboxylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

gamma-glutamyl carboxylase activity

binding [inference]

small molecule binding [inference]

vitamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vitamin k-dependent gamma-carboxylase

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 2** entries
Gene Ontology
gamma-glutamyl carboxylase activity
vitamin binding

Displaying **all 2** entries
InterPro
HTTM
Vitamin K-dependent gamma-carboxylase

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2677	Xenbase:XB-GENE-949715	HUMAN63558
Xenopus tropicalis	56316	Xenbase:XB-GENE-949715
Rattus norvegicus	81716		RATNO31989
Bos taurus	281190		BOVIN02578
Ovis aries	443129		SHEEP13745
Pan troglodytes	459364		PANTR28061
Macaca mulatta	695628		MACMU07732
Monodelphis domestica	100030057		MONDO06286
Equus caballus	100067312		HORSE09521
Ornithorhynchus anatinus	100077833		ORNAN03059

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OrthoDB (Group)

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Acknowledgements