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Guidelines

MIRAGE

serine protease 2

Summary

Gene Symbol

PRSS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5645

PubChem

5645

Alliance of Genome Resources

HGNC:9483

JoGo

PRSS2

TogoVar

PRSS2

Annotation

Keyword

3D-structure
Calcium
Digestion
Direct protein sequencing
Disulfide bond
Metal-binding
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q6PK75
A0A0J9YYC8
Q5NV56
P07478	Anionic trypsinogen Serine protease 2 Trypsin II
A6XMV9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	12731883
proteolysis	IBA
digestion	IEA
antimicrobial humoral response	TAS
extracellular matrix disassembly	TAS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

multicellular organismal process [inference]

digestion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

regulation of cellular process [inference]

regulation of cell adhesion [inference]

positive regulation of cell adhesion

positive regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS
serine-type endopeptidase activity	TAS
serine-type endopeptidase activity	IDA	12709065 12731883
serine-type endopeptidase activity	IBA
calcium ion binding	IDA	12709065

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026