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Guidelines

MIRAGE

serine protease 2

Summary

Gene Symbol

PRSS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5645

PubChem

5645

Alliance of Genome Resources

HGNC:9483

Annotation

Keyword

Calcium
Digestion
Direct protein sequencing
Disulfide bond
Metal-binding
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q6PK75
P07478	Anionic trypsinogen Serine protease 2 Trypsin II
Q5NV56
A6XMV9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	12731883
proteolysis	IBA
digestion	IEA
antimicrobial humoral response	TAS
extracellular matrix disassembly	TAS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

multicellular organismal process [inference]

digestion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

regulation of cellular process [inference]

regulation of cell adhesion [inference]

positive regulation of cell adhesion

positive regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA	12731883
extracellular space	IMP	16192646
extracellular space	IBA
extracellular matrix	TAS	12731883

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS
serine-type endopeptidase activity	TAS
serine-type endopeptidase activity	IDA	12709065 12731883
serine-type endopeptidase activity	IBA
calcium ion binding	IDA	12709065

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **11 - 20** of 37 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Equus caballus	100055297		HORSE32699
Callithrix jacchus	100395240		CALJA43334
Ailuropoda melanoleuca	100472031		AILME07703
Sus scrofa	100525899		PIGXX12381
Pan troglodytes	100615529		PANTR41636
Canis lupus familiaris	100686744		CANLF04451
Sarcophilus harrisii	100913350		SARHA06209
Sarcophilus harrisii	100935321		SARHA06207
Pan paniscus	100991392		PANPA37414
Felis catus	101085707		FELCA03537

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025