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kallikrein related peptidase 7

Summary

Gene Symbol

KLK7

Organism

Homo sapiens (human)

External Links

NCBI Gene

5650

PubChem

5650

Alliance of Genome Resources

HGNC:6368

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P49862	Serine protease 6 Stratum corneum chymotryptic enzyme
B4DHX9
A0A024R4H6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of antibacterial peptide production	IMP	17012259
proteolysis	IEA
epidermis development	TAS	8034709
extracellular matrix disassembly	TAS
protein maturation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cornified envelope	IEA
extracellular region	TAS
extracellular space	IMP	17012259
extracellular space	IBA
secretory granule	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

cornified envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

lamellar body [inference]

epidermal lamellar body

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

lamellar body [inference]

epidermal lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

lamellar body [inference]

epidermal lamellar body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS
serine-type endopeptidase activity	IBA
peptidase activity	IMP	17012259
serine-type peptidase activity	TAS	8034709

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

isoform A

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 51 in total

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Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	3816	RGD:1306420
Rattus norvegicus	5650	RGD:1306420
Rattus norvegicus	13646	RGD:1306420
Rattus norvegicus	13647	RGD:1306420
Rattus norvegicus	13648	RGD:1306420
Rattus norvegicus	16612	RGD:1306420
Rattus norvegicus	16613	RGD:1306420
Rattus norvegicus	16615	RGD:1306420
Rattus norvegicus	16616	RGD:1306420
Rattus norvegicus	16617	RGD:1306420

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Acknowledgements