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MIRAGE
Rap guanine nucleotide exchange factor (GEF) 4

Summary
Gene Symbol
  • Rapgef4
Organism
Mus musculus (house mouse)
NCBI Gene
56508
PubChem
56508
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative promoter usage
  • Alternative splicing
  • Cytoplasm
  • Exocytosis
  • Guanine-nucleotide releasing factor
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Repeat
  • cAMP-binding
Proteins
Displaying all 5 entries
UniProt Protein Name
Q9EQZ6
  • Exchange factor directly activated by cAMP 2
  • Exchange protein directly activated by cAMP 2
  • cAMP-dependent Rap1 guanine-nucleotide exchange factor
  • cAMP-regulated guanine nucleotide exchange factor II
Q9CS95
A2ASW4
  • Exchange factor directly activated by cAMP 2
  • Exchange protein directly activated by cAMP 2
  • cAMP-regulated guanine nucleotide exchange factor II
A2ASW8
  • Exchange factor directly activated by cAMP 2
  • Exchange protein directly activated by cAMP 2
  • cAMP-regulated guanine nucleotide exchange factor II
Q571A8
  • Exchange factor directly activated by cAMP 2
  • Exchange protein directly activated by cAMP 2
  • cAMP-regulated guanine nucleotide exchange factor II
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 19 in total
GO Term Evidence Code PMID
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
small GTPase mediated signal transduction
Ras protein signal transduction
GO Hierarchy
Displaying entries 1 - 5 of 9 in total
GO Term Evidence Code PMID
guanyl-nucleotide exchange factor activity
guanyl-nucleotide exchange factor activity
guanyl-nucleotide exchange factor activity
protein binding
cAMP binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Rap guanine nucleotide exchange factor
Functional Category
  • E: Amino acid transport and metabolism
  • P: Inorganic ion transport and metabolism
  • T: Signal transduction mechanisms
Displaying all 2 entries
Gene Ontology
Ras protein signal transduction
small GTPase-mediated signal transduction
Displaying all 3 entries
InterPro
Cyclic nucleotide-binding domain superfamily
Cyclic nucleotide-binding domain
RmlC-like jelly roll fold
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025