inositol polyphosphate-5-phosphatase E

Summary
Gene Symbol
  • INPP5E
Aliases
  • CORS1
  • PPI5PIV
  • Phosphatidylinositol polyphosphate 5-phosphatase type IV
  • pharbin
Organism
Homo sapiens (human)
External Links
NCBI Gene
56623
HGNC
21474
KEGG Gene ID
hsa:56623
PubChem
56623
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cilium
  • Cytoskeleton
  • Disease variant
  • Golgi apparatus
  • Hydrolase
  • Intellectual disability
  • Joubert syndrome
  • Lipid metabolism
  • Methylation
  • Nucleus
  • Obesity
  • Phosphoprotein
  • Prenylation
  • Reference proteome
  • Repeat
Proteins
Displaying 1 entry
UniProt Protein Name
Q9NRR6
  • 72 kDa inositol polyphosphate 5-phosphatase
  • Inositol polyphosphate-5-phosphatase E
  • Phosphatidylinositol 4,5-bisphosphate 5-phosphatase
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Gene Ontology (GO)
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
inositol polyphosphate 5-phosphatase
Functional Category
  • E: Amino acid transport and metabolism
  • G: Carbohydrate transport and metabolism
  • L: Replication, recombination and repair
Human Protein Atlas
ENSG00000148384

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K20278
Name
inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
References
Disease
Disease Ontology
Displaying all 3 entries
DO ID Disease Name Source
DOID:0050777 Joubert syndrome
DOID:0110980 Joubert syndrome 1
DOID:9970 obesity
The Human Phenotype Ontology
Displaying entries 11 - 20 of 116 in total
HPO ID HPO Term
HP:0000202 Orofacial cleft
HP:0000238 Hydrocephalus
HP:0000252 Microcephaly
HP:0000256 Macrocephaly
HP:0000276 Long face
HP:0000286 Epicanthus
HP:0000368 Low-set, posteriorly rotated ears
HP:0000369 Low-set ears
HP:0000426 Prominent nasal bridge
HP:0000463 Anteverted nares
Displaying all 6 entries
Disease ID Disease Name
ORPHA:475
  • Joubert syndrome
ORPHA:1454
  • COACH syndrome
ORPHA:220493
  • Joubert syndrome with ocular defect
ORPHA:75858
  • MORM syndrome
OMIM:610156
  • MORM syndrome
OMIM:213300
  • Joubert syndrome 1
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP002353
Gene Name
inositol polyphosphate-5-phosphatase, 72 kDa

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024