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ALG2 alpha-1,3/1,6-mannosyltransferase

Summary

Gene Symbol

Alg2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56737

KEGG Gene ID

mmu:56737

PubChem

56737

Alliance of Genome Resources

MGI:1914731

Annotation

Keyword

Endoplasmic reticulum
Glycosyltransferase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9DBE8	Asparagine-linked glycosylation protein 2 homolog GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to calcium ion
oligosaccharide-lipid intermediate biosynthetic process
protein glycosylation	ISO
protein N-linked glycosylation	ISO ISS
dolichol-linked oligosaccharide biosynthetic process	IBA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasmic side of endoplasmic reticulum membrane	ISO ISS
endomembrane system	IBA
nucleus
perinuclear region of cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

endomembrane system

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
alpha-1,3-mannosyltransferase activity	IBA ISO
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	ISO ISS
protein heterodimerization activity
calcium-dependent protein binding
GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity	ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity [inference]

alpha-1,3-mannosyltransferase activity

glycolipid mannosyltransferase activity [inference]

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity

GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

calcium-dependent protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

alpha-1,3/1,6-mannosyltransferase ALG2

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
GDP-Man
GDP-Man
alpha-1,3-mannosyltransferase activity
oligosaccharide-lipid intermediate biosynthetic process
transferase activity

Displaying **all 3** entries
InterPro
Glycosyl transferase, family 1
Glycosyltransferase subfamily 4-like, N-terminal domain
Mannosyltransferase ALG2

KEGG BRITE Database

Orthology

K03843

Name

alpha-1,3/alpha-1,6-mannosyltransferase [EC:2.4.1.132 2.4.1.257]

References

12684507

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05973	2.4.1.132	G65996GC	G53394BX
R06238	2.4.1.257	G53394BX	G43547MI

Rhea

RHEA:29519

GDP-α-D-mannose

H⁺ + GDP

Enzyme

2.4.1.257

PMID

RHEA:29515

GDP-α-D-mannose

H⁺ + GDP

Enzyme

2.4.1.132

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080561	congenital disorder of glycosylation Ii	Alliance of Genome Resources
DOID:0110669	congenital myasthenic syndrome 14	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of **113** in total

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Nannospalax galili	103749080	1026970_0:003dd6	NANGA11144
Rhinopithecus roxellana	104657764		RHIRO15769
Fukomys damarensis	104855510	885580_0:00449b
Pteropus vampyrus	105296247		PTEVA16420
Macaca nemestrina	105477214		MACNE18069
Mandrillus leucophaeus	105549298		MANLE23395
Cercocebus atys	105593038		CERAT33284
Aotus nancymaae	105712992		AOTNA41974
Propithecus coquereli	105805402		PROCO17453
Microcebus murinus	105873779		MICMU11965

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements