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Guidelines

MIRAGE

parathyroid hormone 1 receptor

Summary

Gene Symbol

Pth1r

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

56813

PubChem

56813

Alliance of Genome Resources

RGD:3442

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P25961	PTH/PTHrP type I receptor Parathyroid hormone 1 receptor
A6I3G5	PTH/PTHrP type I receptor Parathyroid hormone 1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISO
ossification	ISO
in utero embryonic development	ISO
in utero embryonic development	IEA
chondrocyte differentiation	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

cell population proliferation

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cell development [inference]

osteoblast development

cell maturation

multicellular organismal process [inference]

ossification

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

cell development [inference]

osteoblast development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cell development [inference]

osteoblast development

cell maturation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cell population proliferation [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

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GO Term	Evidence Code	PMID
nucleolus	ISO
nucleolus	IEA
cytosol	ISO
cytosol	IEA
plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
parathyroid hormone receptor activity	ISO
parathyroid hormone receptor activity	IDA	1313566 19608645 9054374 9642250
parathyroid hormone receptor activity	IBA
parathyroid hormone receptor activity	IEA
G protein-coupled peptide receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

parathyroid hormone parathyroid

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
parathyroid hormone receptor activity
peptide hormone binding

Displaying **all 6** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, parathyroid hormone receptor
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
brush border membrane	PMID:12647298
basolateral plasma membrane	PMID:12647298

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12678	hypercalcemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	799	WB:WBGene00015735
Homo sapiens	5745	Xenbase:XB-GENE-957445	HUMAN69686
Caenorhabditis elegans	10203	WB:WBGene00015735
Caenorhabditis elegans	12311	WB:WBGene00015735
Mus musculus	19228	Xenbase:XB-GENE-957445	MOUSE63583
Caenorhabditis elegans	25029	WB:WBGene00015735
Danio rerio	30629		DANRE28187
Caenorhabditis elegans	31234	WB:WBGene00015735
Caenorhabditis elegans	54598	WB:WBGene00015735
Xenopus tropicalis	56813	Xenbase:XB-GENE-957445

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Last updated: December 8, 2025