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sphingosine kinase 2

Summary

Gene Symbol

SPHK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

56848

HGNC

18859

KEGG Gene ID

hsa:56848

PubChem

56848

Alliance of Genome Resources

HGNC:18859

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoplasm
Endoplasmic reticulum
Kinase
Lipid metabolism
Lysosome
Mitochondrion inner membrane
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KV83
Q9NRA0
E9PCV4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 27 in total

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GO Term	Evidence Code	PMID
phosphorylation	IBA
positive regulation of ceramide biosynthetic process	IDA	16118219
sphinganine-1-phosphate biosynthetic process	IBA IDA	10751414 19729656
negative regulation of cell growth	ISS
regulation of ATP biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

cell population proliferation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

transcription initiation-coupled chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

blood vessel development

animal organ development [inference]

brain development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to oxygen-containing compound [inference]

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of immune response [inference]

positive regulation of mast cell activation involved in immune response

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of leukocyte mediated immunity [inference]

regulation of myeloid leukocyte mediated immunity [inference]

regulation of mast cell degranulation [inference]

positive regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

positive regulation of mast cell degranulation

regulation of immune response [inference]

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of immune response [inference]

positive regulation of mast cell activation involved in immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of interleukin-13 production [inference]

positive regulation of interleukin-13 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of reactive oxygen species biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of interleukin-13 production [inference]

positive regulation of interleukin-13 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of generation of precursor metabolites and energy [inference]

regulation of electron transfer activity [inference]

regulation of cytochrome-c oxidase activity

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

regulation of amide metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of interleukin-13 production [inference]

positive regulation of interleukin-13 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

regulation of protein kinase C signaling [inference]

positive regulation of protein kinase C signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of cytochrome-c oxidase activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of cytochrome-c oxidase activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

regulation of calcium ion import [inference]

positive regulation of calcium ion import

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of cytochrome-c oxidase activity

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

regulation of protein kinase C signaling [inference]

positive regulation of protein kinase C signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of immune response [inference]

positive regulation of mast cell activation involved in immune response

regulation of immune response [inference]

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of immune response [inference]

positive regulation of mast cell activation involved in immune response

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

regulation of protein kinase C signaling [inference]

positive regulation of protein kinase C signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of interleukin-13 production [inference]

positive regulation of interleukin-13 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of generation of precursor metabolites and energy [inference]

regulation of electron transfer activity [inference]

regulation of cytochrome-c oxidase activity

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of ATP biosynthetic process

regulation of ATP metabolic process [inference]

regulation of ATP biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of cytochrome-c oxidase activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of cytochrome-c oxidase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase C signaling

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

negative regulation of cellular process [inference]

negative regulation of cell growth

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of mast cell degranulation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response

regulation of interleukin-13 production [inference]

positive regulation of interleukin-13 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of mast cell activation involved in immune response [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of mast cell activation [inference]

positive regulation of mast cell activation involved in immune response

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of cytochrome-c oxidase activity

regulation of catalytic activity [inference]

regulation of oxidoreductase activity [inference]

regulation of electron transfer activity [inference]

regulation of cytochrome-c oxidase activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	17635916 29615132
intracellular membrane-bounded organelle	IBA
endoplasmic reticulum	ISS
mitochondrial inner membrane	IEA
nucleosome	IDA	19729656

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

nucleosome

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
small GTPase binding		12391145
D-erythro-sphingosine kinase activity	IBA IDA	10751414
histone binding	IDA	19729656
lipid kinase activity
sphinganine kinase activity	IDA	19729656

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

histone binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K04718

Name

sphingosine kinase [EC:2.7.1.91]

References

Rhea

RHEA:51496

ATP + a sphingoid base

H⁺ + ADP + a sphingoid 1-phosphate

Enzyme

2.7.1.91

PMID

RHEA:15465

ATP + sphinganine

H⁺ + ADP + sphinganine 1-phosphate

Enzyme

2.7.1.91

PMID

RHEA:35847

ATP + sphing-4-enine

H⁺ + ADP + sphing-4-enine 1-phosphate

Enzyme

2.7.1.91

PMID

RHEA:33563

ATP + (4R)-hydroxysphinganine

H⁺ + ADP + (4R)-hydroxysphinganine 1-phosphate

Enzyme

2.7.1.91

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050012	chikungunya	DisGeNET
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0060058	lymphoma	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0080001	bone disease	DisGeNET
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET
DOID:0080147	lymphoblastic lymphoma	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001959
Gene Name: sphingosine kinase 2

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	183197	WB:WBGene00007918
Drosophila melanogaster	32089	FB:FBgn0030300
Drosophila melanogaster	326219	FB:FBgn0052484
Danio rerio	100150090	ZFIN:ZDB-GENE-100922-225	DANRE11155
Astyanax mexicanus	103043132		ASTMX09065
Ictalurus punctatus	108264213		ICTPU13298
Salmo trutta	115176532		SALTR84389
Salmo trutta	115189202		SALTR42543
Gadus morhua	115553930		GADMO04069
Oreochromis niloticus	106096428		ORENI08090

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements