GlyCosmos Portal

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GO Term	Evidence Code	PMID
small GTPase binding		12391145
D-erythro-sphingosine kinase activity	IBA IDA	10751414
histone binding	IDA	19729656
lipid kinase activity
sphinganine kinase activity	IDA	19729656

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

histone binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K04718

Name

sphingosine kinase [EC:2.7.1.91]

References

Rhea

RHEA:51496

ATP + a sphingoid base

H⁺ + ADP + a sphingoid 1-phosphate

Enzyme

2.7.1.91

PMID

RHEA:15465

ATP + sphinganine

H⁺ + ADP + sphinganine 1-phosphate

Enzyme

2.7.1.91

PMID

RHEA:35847

ATP + sphing-4-enine

H⁺ + ADP + sphing-4-enine 1-phosphate

Enzyme

2.7.1.91

PMID

RHEA:33563

ATP + (4R)-hydroxysphinganine

H⁺ + ADP + (4R)-hydroxysphinganine 1-phosphate

Enzyme

2.7.1.91

PMID

Disease

Disease Ontology

Displaying entries **161 - 163** of **163** in total

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DO ID	Disease Name	Source
DOID:970	tenosynovitis	DisGeNET
DOID:9952	acute lymphoblastic leukemia	DisGeNET DisGeNET
DOID:9970	obesity	DisGeNET Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001959
Gene Name: sphingosine kinase 2

Ortholog

Displaying entries **11 - 20** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sparus aurata	115567369		SPAAU59856
Xenopus laevis	108696679	Xenbase:XB-GENE-17346103
Xenopus laevis	108697745	Xenbase:XB-GENE-6487776
Xenopus tropicalis	100494664	Xenbase:XB-GENE-991354
Ornithorhynchus anatinus	100087297		ORNAN00811
Callithrix jacchus	100387720		CALJA24447
Cercocebus atys	105595245		CERAT28494
Macaca mulatta	718088		MACMU18024
Macaca nemestrina	105478648		MACNE39731
Mandrillus leucophaeus	105539178		MANLE32656

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements