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proteasome 20S subunit alpha 3

Summary

Gene Symbol

PSMA3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5684

PubChem

5684

Alliance of Genome Resources

HGNC:9532

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Proteasome
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P25788	Macropain subunit C8 Multicatalytic endopeptidase complex subunit C8 Proteasome component C8
A0A140VK43

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	26524591
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
regulation of endopeptidase activity

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
nucleus	HDA	21630459
nucleoplasm	TAS
cytoplasm	TAS	16130169
cytoplasm	IDA	34711951
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome core complex, alpha-subunit complex

intracellular protein-containing complex [inference]

catalytic complex [inference]

proteasome core complex

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11146632 12376572 12826010 14733938 15225636 16169070 17948026 19208651 21516116 21900206 21988832 22659184 24722188 25416956 25599644 25910212 26871637 29568061 29636472 29892012 31515488 32296183 32814053 33961781 34702852 35271311 35858375
ubiquitin protein ligase binding	IPI	16207813

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proteasome

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
proteasomal protein catabolic process
proteolysis involved in protein catabolic process

Displaying **all 4** entries
InterPro
Nucleophile aminohydrolases, N-terminal
Proteasome alpha-subunit, N-terminal domain
Proteasome alpha-type subunit
Proteasome, subunit alpha/beta

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5684	Xenbase:XB-GENE-976787
Mus musculus	19167	Xenbase:XB-GENE-976787	MOUSE08791
Rattus norvegicus	29670		RATNO36354
Rattus norvegicus	408248		RATNO36354
Pan troglodytes	467469		PANTR08854
Canis lupus familiaris	480338		CANLF17952
Bos taurus	505176		BOVIN01479
Danio rerio	564370		DANRE11730
Macaca mulatta	700251		MACMU40310
Monodelphis domestica	100021131		MONDO03957