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RAD18 E3 ubiquitin protein ligase

Summary

Gene Symbol

RAD18

Organism

Homo sapiens (human)

External Links

NCBI Gene

56852

PubChem

56852

Alliance of Genome Resources

HGNC:18278

Annotation

Keyword

3D-structure
Acetylation
Cytoskeleton
DNA repair
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NS91	Postreplication repair protein RAD18 RING finger protein 73 RING-type E3 ubiquitin transferase RAD18

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
DNA repair	NAS	10884424
postreplication repair	IBA
protein monoubiquitination	IBA
cellular response to DNA damage stimulus	IDA	22036607 25023518 25931565
DNA damage response	IDA	22036607 25023518 25931565

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

postreplication repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

postreplication repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

postreplication repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

postreplication repair

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of chromosome segregation [inference]

positive regulation of chromosome segregation

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	10884424
nucleus	IDA	15632077 22036607 25023518
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

Rad6-Rad18 complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

Rad6-Rad18 complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

nuclear inclusion body

microtubule organizing center [inference]

centrosome

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
Y-form DNA binding	IDA	18363965
damaged DNA binding	NAS	10884424
single-stranded DNA binding	IEA
protein binding	IPI	18316726 18719106 19549727 21422291 21659603 22036607 22681887 24981860 25416956 25931565 26496610 28514442 32296183 32814053 33961781 35849344
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

identical protein binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

Y-form DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase rad18

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
DNA repair
metal ion binding
postreplication repair
protein monoubiquitination
protein ubiquitination

Displaying **all 6** entries
InterPro
E3 ubiquitin-protein ligase Rad18
Rad18, zinc finger UBZ4-type
SAP domain
Zinc finger, RING-type, conserved site
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	56852	Xenbase:XB-GENE-17330300
Mus musculus	58186		MOUSE49862
Rattus norvegicus	362412		RATNO32132
Danio rerio	393106		DANRE37789
Pan troglodytes	460144		PANTR30331
Canis lupus familiaris	476544		CANLF07309
Bos taurus	514440		BOVIN17423
Macaca mulatta	704708		MACMU30352
Monodelphis domestica	100023569		MONDO30425
Equus caballus	100052645		HORSE10982