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core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Summary

Gene Symbol

C1GALT1

Aliases

C1GALT
T-synthase
core 1 beta3-Gal-T

Organism

Homo sapiens (human)

External Links

NCBI Gene

56913

GGDB ID

gg075

HGNC

24337

mRNA

NM_020156

map

7p14-p13

Protein

NP_064541

OMIM

610555

KEGG Gene ID

hsa:56913

PubChem

56913

Alliance of Genome Resources

HGNC:24337

Annotation

Keyword

Alternative splicing
Angiogenesis
Developmental protein
Differentiation
Disulfide bond
Glycosyltransferase
Manganese
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A024RA32	Core 1 O-glycan T-synthase Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 Core 1 beta1,3-galactosyltransferase 1
Q9NS00	B3Gal-T8 Core 1 O-glycan T-synthase Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 Core 1 beta1,3-galactosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
angiogenesis	IMP	17228361
kidney development	IMP	17228361
protein O-linked glycosylation	IEA
intestinal epithelial cell development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

intestinal epithelial cell development

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

intestinal epithelial cell development

animal organ development [inference]

kidney development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

intestinal epithelial cell development

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
membrane	IDA	11677243

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein binding	IPI	21496458
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	IDA	11677243
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

beta-1,3-galactosyltransferase activity [inference]

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

Displaying **all 2** entries
InterPro
C1GALT1/C1GALT1-specific chaperone 1
Fringe-like, glycosyltransferase domain

Human Protein Atlas

ENSG00000106392

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg075

Gene Symbol

C1GALT1

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243
UDP-Gal	G57321FI	O-glycan Synthesis	G00031MO	O-glycan Synthesis
UDP-Gal	G57321FI	PSGL-1(EYEYLDYDFLPETEPPEM)	G00031MO	PSGL-1(EYEYLDYDFLPETEPPEM)	11677243

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-Gal	G00035MO	O-glycan Synthesis

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_723428	NM_164840
Caenorhabditis elegans	NP_499293	NM_066892
Mus musculus	NP_443719	NM_052993
Rattus norvegicus	NP_075239	NM_022950

KEGG BRITE Database

Orthology

K00731

Name

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122]

References

11677243

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05908	2.4.1.122	G57321FI	G00031MO

Rhea

RHEA:15621

an N-acetyl-α-D-galactosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.122

PMID

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	32896	Xenbase:XB-GENE-992000
Xenopus tropicalis	33482	Xenbase:XB-GENE-992000
Xenopus tropicalis	33485	Xenbase:XB-GENE-992000
Xenopus tropicalis	34215	Xenbase:XB-GENE-992000
Xenopus tropicalis	35792	Xenbase:XB-GENE-992000
Danio rerio	38106	ZFIN:ZDB-GENE-060503-810
Xenopus tropicalis	56913	Xenbase:XB-GENE-992000
Rattus norvegicus	65044	Xenbase:XB-GENE-992000	RATNO29866
Mus musculus	94192	Xenbase:XB-GENE-992000	MOUSE51076
Xenopus tropicalis	176455	Xenbase:XB-GENE-992000

GlyTouCan

GlyComb

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UniCarb-DR

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements