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proteasome 20S subunit beta 4

Summary

Gene Symbol

PSMB4

Organism

Homo sapiens (human)

External Links

NCBI Gene

5692

PubChem

5692

Alliance of Genome Resources

HGNC:9541

JoGo

PSMB4

TogoVar

PSMB4

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Host-virus interaction
Nucleus
Phosphoprotein
Proteasome
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P28070	26 kDa prosomal protein Macropain beta chain Multicatalytic endopeptidase complex beta chain Proteasome beta chain Proteasome chain 3 Proteasome subunit beta-7
A0A140VK46

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of inflammatory response to antigenic stimulus	IEA
proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	26524591
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

regulation of inflammatory response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

regulation of inflammatory response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to antigenic stimulus

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
proteasome complex	NAS	29636472
proteasome complex	IDA	17323924 26524591
nucleus	TAS	16130169
nucleus	IDA	34711951
nucleus	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome core complex, beta-subunit complex

intracellular protein-containing complex [inference]

catalytic complex [inference]

proteasome core complex

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lipopolysaccharide binding	IEA
protein binding	IPI	15231748 17189198 17948026 25416956 28514442 32296183 32814053 33961781 35271311

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

lipopolysaccharide binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proteasome

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis involved in protein catabolic process
threonine-type endopeptidase activity

Displaying **all 5** entries
InterPro
Nucleophile aminohydrolases, N-terminal
Peptidase T1A, proteasome beta-subunit
Proteasome B-type subunit
Proteasome beta-type subunit, conserved site
Proteasome, subunit alpha/beta